Literature DB >> 22450612

Getting Past "g": testing a new model of dementing processes in persons without dementia.

Donald R Royall1, Raymond F Palmer.   

Abstract

The cognitive correlates of functional status are essential to dementia case-finding. The authors have used structural-equation models to explicitly distinguish dementia-relevant variance in cognitive task performance (i.e., δ) from the variance that is unrelated to a dementing process (i.e., g'). Together, g' and δ comprise Spearman's "g." Although δ represents only a small fraction of the total variance in cognitive task performance, it is more strongly associated with dementia severity than is g'. In this analysis, the authors test whether δ can predict future cognitive decline in persons clinically without dementia at baseline. These results have implications for the clinical assessment of dementia and suggest that functional status should assume a more important role.

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Year:  2012        PMID: 22450612     DOI: 10.1176/appi.neuropsych.11040078

Source DB:  PubMed          Journal:  J Neuropsychiatry Clin Neurosci        ISSN: 0895-0172            Impact factor:   2.198


  11 in total

1.  The δ latent dementia phenotype in the uniform data set: Cross-validation and extension.

Authors:  Brandon E Gavett; Vanessa Vudy; Mary Jeffrey; Samantha E John; Ashita S Gurnani; Jason W Adams
Journal:  Neuropsychology       Date:  2014-08-25       Impact factor: 3.295

2.  The default mode network may be the key substrate of depressive symptom-related cognitive changes.

Authors:  Donald R Royall; Raymond F Palmer; Eric D Vidoni; Robyn A Honea
Journal:  J Alzheimers Dis       Date:  2013       Impact factor: 4.472

3.  The default mode network and related right hemisphere structures may be the key substrates of dementia.

Authors:  Donald R Royall; Raymond F Palmer; Eric D Vidoni; Robyn A Honea; Jeffrey M Burns
Journal:  J Alzheimers Dis       Date:  2012       Impact factor: 4.472

4.  The effectiveness and unique contribution of neuropsychological tests and the δ latent phenotype in the differential diagnosis of dementia in the uniform data set.

Authors:  Samantha E John; Ashita S Gurnani; Cara Bussell; Jessica L Saurman; Jason W Griffin; Brandon E Gavett
Journal:  Neuropsychology       Date:  2016-11       Impact factor: 3.295

5.  The Role of Alzheimer's and Cerebrovascular Pathology in Mediating the Effects of Age, Race, and Apolipoprotein E Genotype on Dementia Severity in Pathologically-Confirmed Alzheimer's Disease.

Authors:  Brandon E Gavett; Samantha E John; Ashita S Gurnani; Cara A Bussell; Jessica L Saurman
Journal:  J Alzheimers Dis       Date:  2016       Impact factor: 4.472

6.  Serum interleukin (IL)-15 as a biomarker of Alzheimer's disease.

Authors:  Ram J Bishnoi; Raymond F Palmer; Donald R Royall
Journal:  PLoS One       Date:  2015-02-24       Impact factor: 3.240

7.  "Executive functions" cannot be distinguished from general intelligence: two variations on a single theme within a symphony of latent variance.

Authors:  Donald R Royall; Raymond F Palmer
Journal:  Front Behav Neurosci       Date:  2014-10-24       Impact factor: 3.558

8.  Development of a model on factors affecting instrumental activities of daily living in people with mild cognitive impairment - a Delphi study.

Authors:  Marina Bruderer-Hofstetter; Sietske A M Sikkes; Thomas Münzer; Karin Niedermann
Journal:  BMC Neurol       Date:  2020-07-01       Impact factor: 2.474

9.  Utility of Machine Learning Approach with Neuropsychological Tests in Predicting Functional Impairment of Alzheimer's Disease.

Authors:  Seyul Kwak; Dae Jong Oh; Yeong-Ju Jeon; Da Young Oh; Su Mi Park; Hairin Kim; Jun-Young Lee
Journal:  J Alzheimers Dis       Date:  2022       Impact factor: 4.472

10.  Aging is a weak but relentless determinant of dementia severity.

Authors:  Donald R Royall; Raymond F Palmer
Journal:  Oncotarget       Date:  2016-03-22
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