| Literature DB >> 22450263 |
Shuo Shen1, Guoyu Li, Jian Huang, Chaojun Chen, Bu Ren, Ga Lu, Yong Tan, Jiaxu Zhang, Xian Li, Jinhui Wang.
Abstract
Five new steroidal saponins, Pallidifloside D (1), Pallidifloside E (2), Pallidifloside G (5), Pallidifloside H (6) and Pallidifloside I (7), together with seven other steroidal saponins (3, 4, 8-12) were isolated from the dry bulbs of Fritillaria pallidiflora Schrenk. Their structures were established by spectroscopic techniques (IR, MS, 1D and 2D NMR) and chemical means. The isolated steroidal saponins were evaluated for cyotoxic activity against human C6 brain gliomas and Hela cervix cancer cell lines using MTT assays. Compounds 1, 10, 11, 12 showed cytotoxicity against C6 and Hela cell lines with IC(50) values in the range of 5.1-75.8μM.Entities:
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Year: 2012 PMID： 22450263 DOI： 10.1016/j.fitote.2012.03.008
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882