PURPOSE OF REVIEW: The advancement of optical coherence tomography has improved the resolution of in-vivo images of the retina. This has led to a wealth of novel knowledge regarding the microstructures of the photoreceptor layer and its relationship with visual functions under different pathological diseases. RECENT FINDINGS: Identification of the hyperreflective lines in the photoreceptor layer has been made possible by spectral domain optical coherence tomography. The inner segment/outer segment junction, external limiting membrane, cone outer segment tips, and the retinal pigment epithelium were thought to be the origins of the four hyperreflective lines seen in the photoreceptor layer. Integrity of these lines has been linked with visual functions in various retinopathies, and has been suggested to carry prognostic implications. Recovery of initially interrupted lines has been documented following successful treatment. SUMMARY: Identification of these hyperreflective lines may have clinical implications as visual function was found to correlate closely with their integrity. Restoration of these lines may indicate treatment response and potential visual recovery.
PURPOSE OF REVIEW: The advancement of optical coherence tomography has improved the resolution of in-vivo images of the retina. This has led to a wealth of novel knowledge regarding the microstructures of the photoreceptor layer and its relationship with visual functions under different pathological diseases. RECENT FINDINGS: Identification of the hyperreflective lines in the photoreceptor layer has been made possible by spectral domain optical coherence tomography. The inner segment/outer segment junction, external limiting membrane, cone outer segment tips, and the retinal pigment epithelium were thought to be the origins of the four hyperreflective lines seen in the photoreceptor layer. Integrity of these lines has been linked with visual functions in various retinopathies, and has been suggested to carry prognostic implications. Recovery of initially interrupted lines has been documented following successful treatment. SUMMARY: Identification of these hyperreflective lines may have clinical implications as visual function was found to correlate closely with their integrity. Restoration of these lines may indicate treatment response and potential visual recovery.
Authors: Karen B Schaal; K Bailey Freund; Katie M Litts; Yuhua Zhang; Jeffrey D Messinger; Christine A Curcio Journal: Retina Date: 2015-07 Impact factor: 4.256
Authors: Tobias Duncker; Marcela Marsiglia; Winston Lee; Jana Zernant; Stephen H Tsang; Rando Allikmets; Vivienne C Greenstein; Janet R Sparrow Journal: Invest Ophthalmol Vis Sci Date: 2014-10-23 Impact factor: 4.799
Authors: Tobias Duncker; Winston Lee; Fan Jiang; Rithambara Ramachandran; Donald C Hood; Stephen H Tsang; Janet R Sparrow; Vivienne C Greenstein Journal: Retina Date: 2018-01 Impact factor: 4.256
Authors: Paolo Tortorella; Enzo D'Ambrosio; Ludovico Iannetti; Federica De Marco; Maurizio La Cava Journal: Biomed Res Int Date: 2015-06-08 Impact factor: 3.411