| Literature DB >> 22449571 |
Ina Olmer Specht1, Karin S Hougaard2, Marcello Spanò3, Davide Bizzaro4, Gian Carlo Manicardi5, Christian H Lindh6, Gunnar Toft7, Bo A G Jönsson6, Aleksander Giwercman8, Jens Peter E Bonde9.
Abstract
Perfluoroalkyl substances (PFASs) can interfere with male reproductive function, but evidence in humans is limited. Six hundred four fertile men (199 from Greenland, 197 from Poland and 208 from Ukraine) were enrolled in the study. We measured four PFASs in serum (PFOS, PFOA, PFNA and PFHxS) and concurrent DNA damage in spermatozoa by sperm chromatin structure assay (SCSA) and in situ terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay, apoptotic markers in semen (Fas-receptor and Bcl-xL), and reproductive hormones in serum. No association between PFASs and SCSA, apoptotic markers or reproductive hormones emerged. We observed a slight increase in SHBG and TUNEL-positivity with increased PFOA exposure in men from Greenland. Thus, consistent evidence that PFAS exposure interferes with sperm DNA fragmentation, apoptosis or reproductive hormones was not found.Entities:
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Year: 2012 PMID： 22449571 DOI： 10.1016/j.reprotox.2012.02.008
Source DB: PubMed Journal: Reprod Toxicol ISSN： 0890-6238 Impact factor: 3.143