Literature DB >> 22449248

A practical preparation of highly versatile N-acylpyrroles from 2,4,4-trimethoxybutan-1-amine.

Tomoaki Maehara1, Rentaro Kanno, Satoshi Yokoshima, Tohru Fukuyama.   

Abstract

A novel method for the preparation of N-acylpyrrole is described. The method involves condensation of carboxylic acids with 2,4,4-trimethoxybutan-1-amine, followed by acid-mediated cyclization to form the pyrrole ring. The preparative procedure is highly tolerant of a variety of functional groups.

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Year:  2012        PMID： 22449248     DOI： 10.1021/ol3005613

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  2 in total

1.  A mild and efficient AgSbF6-catalyzed synthesis of fully substituted pyrroles through a sequential propargylation/amination/cycloisomerization reaction.

Authors:  Satheesh Gujarathi; Xingui Liu; Lin Song; Howard Hendrickson; Guangrong Zheng
Journal:  Tetrahedron       Date:  2014-08-26       Impact factor: 2.457

2.  Synthesis of Pyrrolopyrazinones by Construction of the Pyrrole Ring onto an Intact Diketopiperazine.

Authors:  Susanna K Maisto; Angela P Leersnyder; Gwyneth L Pudner; Jonathan R Scheerer
Journal:  J Org Chem       Date:  2020-06-30       Impact factor: 4.354
  2 in total

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