Literature DB >> 2244920

Essential role of nitric oxide in descending inhibition in the rat proximal colon.

F Hata1, T Ishii, A Kanada, N Yamano, T Kataoka, T Takeuchi, O Yagasaki.   

Abstract

Possible mediators of descending inhibition in the rat proximal colon were studied. Localized distension with a small balloon caused relaxation of the circular muscle on the anal side of the distended region. This relaxation was still observed after the colonic segment had been desensitized to ATP, neurotensin and vasoactive intestinal peptide, so these compounds seem unlikely to mediate descending inhibition. Nitro-arginine inhibited the relaxation induced by the distension, and L-arginine counteracted the effect of nitro-arginine. Nitric oxide, isoamylnitrate and sodium nitroprusside caused relaxation. These results strongly suggest an essential role of nitric oxide in descending relaxation in the rat proximal colon.

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Year:  1990        PMID： 2244920     DOI： 10.1016/0006-291x(90)91605-r

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  18 in total

1.  VIP- and PACAP-mediated nonadrenergic, noncholinergic inhibition in longitudinal muscle of rat distal colon: involvement of activation of charybdotoxin- and apamin-sensitive K+ channels.

Authors:  M Kishi; T Takeuchi; N Suthamnatpong; T Ishii; H Nishio; F Hata; T Takewaki
Journal:  Br J Pharmacol       Date:  1996-10       Impact factor: 8.739

2.  Projections of nitric oxide synthesizing neurons in the guinea-pig colon.

Authors:  K McConalogue; J B Furness
Journal:  Cell Tissue Res       Date:  1993-03       Impact factor: 5.249

3.  Distribution and morphological features of nitrergic neurons in the porcine large intestine.

Authors:  M Barbiers; J P Timmermans; D W Scheuermann; D Adriaensen; B Mayer; M H De Groodt-Lasseel
Journal:  Histochemistry       Date:  1993-07

4.  Distribution of nitric oxide synthase-containing nerves in the aganglionic intestine of mutant rats: a histochemical study.

Authors:  M Teramoto; T Domoto; K Tanigawa; Y Yasui; K Tamura
Journal:  J Gastroenterol       Date:  1996-04       Impact factor: 7.527

5.  Nitric oxide donating compounds stimulate human colonic ion transport in vitro.

Authors:  W A Stack; B Filipowicz; C J Hawkey
Journal:  Gut       Date:  1996-07       Impact factor: 23.059

6.  Tonic inhibitory action by nitric oxide on spontaneous mechanical activity in rat proximal colon: involvement of cyclic GMP and apamin-sensitive K+ channels.

Authors:  F Mulè; S D'Angelo; R Serio
Journal:  Br J Pharmacol       Date:  1999-05       Impact factor: 8.739

7.  A possible role of neurotensin in NANC relaxation of longitudinal muscle of the jejunum and ileum of Wistar rats.

Authors:  Michiru Yamaji; Mayuko Ohta; Yasuko Yamazaki; Kaori Fujinami; Akikazu Fujita; Tadayoshi Takeuchi; Fumiaki Hata; Tadashi Takewaki
Journal:  Br J Pharmacol       Date:  2002-11       Impact factor: 8.739

8.  Mediators of nonadrenergic, noncholinergic inhibition in the proximal, middle and distal regions of rat colon.

Authors:  N Suthamnatpong; F Hata; A Kanada; T Takeuchi; O Yagasaki
Journal:  Br J Pharmacol       Date:  1993-02       Impact factor: 8.739

9.  Inhibition of rat colon contractility by prostacyclin (IP-) receptor agonists: involvement of NANC neurotransmission.

Authors:  Y M Qian; R L Jones
Journal:  Br J Pharmacol       Date:  1995-05       Impact factor: 8.739

Review 10.  Nitric oxide, a biological effector. Electron paramagnetic resonance detection of nitrosyl-iron-protein complexes in whole cells.

Authors:  Y Henry; C Ducrocq; J C Drapier; D Servent; C Pellat; A Guissani
Journal:  Eur Biophys J       Date:  1991       Impact factor: 1.733
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