BACKGROUND: Allergic rhinitis (AR) is one of the most common diseases caused by the combined effects of intrinsic factors (susceptibility genes and immunological status) and the external environment. Analyses of ascendant family history of atopic disease suggest that AR and atopic dermatitis might share a similar genetic background. OBJECTIVE: To conduct a case-control study in a Chinese Han population to evaluate the potential influence of single nucleotide polymorphisms (SNPs) at FLG, 5q22.1, 11q13.5, 14q11.2 and 20q13.33 on AR. METHODS: Ten SNPs--rs11204971 and rs3126085 at FLG, rs10067777, rs7701890, rs13360927, and rs13361382 at 5q22.1, rs6010620 at 20q13.33, rs7936562 and rs7124842 at 11q13.5, and rs4982958 at 14q11.2 were genotyped in 363 cases and 668 controls using the Sequenom MassArray system. Data were analyzed with PLINK 1.07 software. RESULTS: The T allele of rs4982958 at 14q11.2 was observed to be significantly associated with AR (P = .002, OR = 0.73, P(Bonferront) = .02). Genotype-based association testing revealed that the recessive model might provide the best fit for rs4982958 (P(Bonferroni) = .01). In subphenotype analyses, the rs4982958 T allele was also significantly associated with persistent AR (P = .01) and more than 2 positive skin prick tests (P = .038). CONCLUSION: We identified a novel susceptibility locus 14q11.2 for AR that might bear candidate genes conferring susceptibility to AR and affecting disease phenotypes.
BACKGROUND:Allergic rhinitis (AR) is one of the most common diseases caused by the combined effects of intrinsic factors (susceptibility genes and immunological status) and the external environment. Analyses of ascendant family history of atopic disease suggest that AR and atopic dermatitis might share a similar genetic background. OBJECTIVE: To conduct a case-control study in a Chinese Han population to evaluate the potential influence of single nucleotide polymorphisms (SNPs) at FLG, 5q22.1, 11q13.5, 14q11.2 and 20q13.33 on AR. METHODS: Ten SNPs--rs11204971 and rs3126085 at FLG, rs10067777, rs7701890, rs13360927, and rs13361382 at 5q22.1, rs6010620 at 20q13.33, rs7936562 and rs7124842 at 11q13.5, and rs4982958 at 14q11.2 were genotyped in 363 cases and 668 controls using the Sequenom MassArray system. Data were analyzed with PLINK 1.07 software. RESULTS: The T allele of rs4982958 at 14q11.2 was observed to be significantly associated with AR (P = .002, OR = 0.73, P(Bonferront) = .02). Genotype-based association testing revealed that the recessive model might provide the best fit for rs4982958 (P(Bonferroni) = .01). In subphenotype analyses, the rs4982958 T allele was also significantly associated with persistent AR (P = .01) and more than 2 positive skin prick tests (P = .038). CONCLUSION: We identified a novel susceptibility locus 14q11.2 for AR that might bear candidate genes conferring susceptibility to AR and affecting disease phenotypes.
Authors: Chun Wei Li; De Hua Chen; Jia Tao Zhong; Zhi Bin Lin; Hua Peng; Han Gui Lu; Yan Yang; Jia Yin; Tian Ying Li Journal: PLoS One Date: 2014-12-16 Impact factor: 3.240
Authors: Daniel E Miller; Carmy Forney; Mark Rochman; Stacey Cranert; Jeffery Habel; Jeffrey Rymer; Arthur Lynch; Connor Schroeder; Josh Lee; Amber Sauder; Quinton Smith; Mehak Chawla; Michael P Trimarchi; Xiaoming Lu; Ellen Fjellman; Michael Brusilovsky; Artem Barski; Stephen Waggoner; Matthew T Weirauch; Marc E Rothenberg; Leah C Kottyan Journal: G3 (Bethesda) Date: 2019-03-07 Impact factor: 3.154
Authors: Leah C Kottyan; Avery Maddox; Julian R Braxton; Emily M Stucke; Vince Mukkada; Philip E Putnam; J Pablo Abonia; Mirna Chehade; Robert A Wood; Robbie D Pesek; Brian P Vickery; Glenn T Furuta; Peter Dawson; Hugh A Sampson; Lisa J Martin; Jennifer A Kelly; Robert P Kimberly; Kathy Sivils; Patrick M Gaffney; Kenneth Kaufman; John B Harley; Marc E Rothenberg Journal: Genes Immun Date: 2018-06-08 Impact factor: 2.676