BACKGROUND: There are few data that demonstrate a significant effect of aspirin therapy for diabetic patients. To clarify the effect of the primary prevention of aspirin therapy in diabetic patients, the relationship between blood pressure (BP) and the incidence of atherosclerotic events was investigated in participants in the Japanese primary prevention of atherosclerosis with aspirin for diabetes (JPAD) trial. METHODS AND RESULTS: We divided the JPAD participants according to their systolic (SBP) and diastolic (DBP) BPs at enrollment (SBP≥140 mmHg and/or DBP ≥90 mmHg: unattained group, SBP <140 mmHg and DBP <90 mmHg: attained group). The incidence of the primary atherosclerotic events, especially cerebrovascular events, was higher in the unattained group than in the attained group. The incidence of cerebrovascular events was higher in the unattained group than in the attained group in patients without aspirin therapy; however, the incidence of cerebrovascular events in the unattained group was as low as the incidence in the attained group in patients undergoing aspirin therapy. Cox proportional hazards analysis revealed that BP level was an independent predictor for cerebrovascular events in diabetic patients. CONCLUSIONS:Aspirin therapy may reduce cerebrovascular events in diabetic patients with higher BP. Aspirin therapy could be an additional strategy as primary prevention for diabetic patients with higher BP.
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BACKGROUND: There are few data that demonstrate a significant effect of aspirin therapy for diabeticpatients. To clarify the effect of the primary prevention of aspirin therapy in diabeticpatients, the relationship between blood pressure (BP) and the incidence of atherosclerotic events was investigated in participants in the Japanese primary prevention of atherosclerosis with aspirin for diabetes (JPAD) trial. METHODS AND RESULTS: We divided the JPAD participants according to their systolic (SBP) and diastolic (DBP) BPs at enrollment (SBP ≥140 mmHg and/or DBP ≥90 mmHg: unattained group, SBP <140 mmHg and DBP <90 mmHg: attained group). The incidence of the primary atherosclerotic events, especially cerebrovascular events, was higher in the unattained group than in the attained group. The incidence of cerebrovascular events was higher in the unattained group than in the attained group in patients without aspirin therapy; however, the incidence of cerebrovascular events in the unattained group was as low as the incidence in the attained group in patients undergoing aspirin therapy. Cox proportional hazards analysis revealed that BP level was an independent predictor for cerebrovascular events in diabeticpatients. CONCLUSIONS:Aspirin therapy may reduce cerebrovascular events in diabeticpatients with higher BP. Aspirin therapy could be an additional strategy as primary prevention for diabeticpatients with higher BP.
Authors: James F Meschia; Cheryl Bushnell; Bernadette Boden-Albala; Lynne T Braun; Dawn M Bravata; Seemant Chaturvedi; Mark A Creager; Robert H Eckel; Mitchell S V Elkind; Myriam Fornage; Larry B Goldstein; Steven M Greenberg; Susanna E Horvath; Costantino Iadecola; Edward C Jauch; Wesley S Moore; John A Wilson Journal: Stroke Date: 2014-10-28 Impact factor: 7.914
Authors: Marcello Casaccia Bertoluci; Rodrigo Oliveira Moreira; André Faludi; Maria Cristina Izar; Beatriz D Schaan; Cynthia Melissa Valerio; Marcelo Chiara Bertolami; Ana Paula Chacra; Marcus Vinicius Bolivar Malachias; Sérgio Vencio; José Francisco Kerr Saraiva; Roberto Betti; Luiz Turatti; Francisco Antonio Helfenstein Fonseca; Henrique Tria Bianco; Marta Sulzbach; Adriana Bertolami; João Eduardo Nunes Salles; Alexandre Hohl; Fábio Trujilho; Eduardo Gomes Lima; Marcio Hiroshi Miname; Maria Teresa Zanella; Rodrigo Lamounier; João Roberto Sá; Celso Amodeo; Antonio Carlos Pires; Raul D Santos Journal: Diabetol Metab Syndr Date: 2017-07-14 Impact factor: 3.320