BACKGROUND: The seasonal influenza vaccination programme in England targets individuals over 65 years old and in clinical risk groups. METHODS: A model of influenza transmission and disease was fitted to weekly primary care consultations due to influenza in a typical pre-pandemic season (2006/2007). Different scenarios were constructed about influenza severity and how well vaccines match circulating strains to assess the impact and cost-effectiveness of the current vaccination programme. RESULTS: A well-matched vaccine may reduce the incidence of laboratory-confirmed influenza illness from 8.2% (95% range 4.3-13%) to 5.9% (95% range 2.9-9.7%), with 56-73% of this due to indirect protection. The programme is likely to be cost-effective unless both low severity and poor matching is assumed. CONCLUSION: The current seasonal influenza vaccination programme appears to substantially reduce disease burden and provides good value for money.
BACKGROUND: The seasonal influenza vaccination programme in England targets individuals over 65 years old and in clinical risk groups. METHODS: A model of influenza transmission and disease was fitted to weekly primary care consultations due to influenza in a typical pre-pandemic season (2006/2007). Different scenarios were constructed about influenza severity and how well vaccines match circulating strains to assess the impact and cost-effectiveness of the current vaccination programme. RESULTS: A well-matched vaccine may reduce the incidence of laboratory-confirmed influenza illness from 8.2% (95% range 4.3-13%) to 5.9% (95% range 2.9-9.7%), with 56-73% of this due to indirect protection. The programme is likely to be cost-effective unless both low severity and poor matching is assumed. CONCLUSION: The current seasonal influenza vaccination programme appears to substantially reduce disease burden and provides good value for money.
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Authors: Peng-Jun Lu; James A Singleton; Gary L Euler; Walter W Williams; Carolyn B Bridges Journal: Am J Epidemiol Date: 2013-09-05 Impact factor: 4.897
Authors: Peng-Jun Lu; Alissa O'Halloran; Leah Bryan; Erin D Kennedy; Helen Ding; Samuel B Graitcer; Tammy A Santibanez; Ankita Meghani; James A Singleton Journal: Am J Infect Control Date: 2014-05-03 Impact factor: 2.918
Authors: Peng-Jun Lu; Mei-Chuan Hung; Alissa C O'Halloran; Helen Ding; Anup Srivastav; Walter W Williams; James A Singleton Journal: Am J Prev Med Date: 2019-08-29 Impact factor: 5.043
Authors: Peng-Jun Lu; Anup Srivastav; Tammy A Santibanez; M Christopher Stringer; Michael Bostwick; Jill A Dever; Marshica Stanley Kurtz; Walter W Williams Journal: Vaccine Date: 2017-07-01 Impact factor: 3.641