| Literature DB >> 224461 |
L P Renaud, H W Blume, Q J Pittman, Y Lamour, A T Tan.
Abstract
The microiontophoretic application of thyrotropin-releasing hormone causes a selective reduction in neuronal excitation evoked by L-glutamate but not by acetylcholine in rat cerebral cortex. Thyrotropin-releasing hormone has no influence on the activity of acetylcholinesterase or on choline uptake and release from cerebral synaptosomes. This evidence for a selective interaction between a centrally acting peptide and an excitatory amino acid neurotransmitter may indicate a specific locus of thyrotropin-releasing hormone action at glutamate-activated receptor sites.Entities:
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Year: 1979 PMID： 224461 DOI： 10.1126/science.224461
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728