BACKGROUND: In white populations, age seems to modify the effect of sex on stroke risk, and compared with men, women are protected from stroke until approximately age 75 to 85 years, after which the protection is lost or reversed. Compared with non-Hispanic whites (NHWs), Mexican Americans (MAs) are at higher risk of stroke; however, age- and sex-specific stroke incidence data are currently not available for this population. OBJECTIVE: This study was performed to compare the age-specific sex differences in stroke risk in MAs and NHWs. METHODS: Data were derived from the BASIC (Brain Attack Surveillance in Corpus Christi) Project, a population-based stroke surveillance study conducted in Nueces County Texas. Incident strokes (n = 2421, including ischemic stroke, intracerebral hemorrhage, and subarachnoid hemorrhage) that occurred between January 1, 2000 and May 25, 2007 in individuals aged 45 years or older were included in the analysis. Poisson regression using the generalized additive models framework was used to analyze the relationship between sex, age (5-year intervals), and race/ethnicity (NHW or MA) and incident stroke risk. RESULTS: Among both NHWs and MAs aged 45 to 79 years, men were at higher risk of stroke than women were. The magnitude of increased stroke risk in men compared with women diminished with age, and after age 79 years, no sex difference in stroke risk was observed. CONCLUSIONS: Reasons for the loss of protection from stroke in aging women of all races/ethnicities are not fully understood, and further study is warranted.
BACKGROUND: In white populations, age seems to modify the effect of sex on stroke risk, and compared with men, women are protected from stroke until approximately age 75 to 85 years, after which the protection is lost or reversed. Compared with non-Hispanic whites (NHWs), Mexican Americans (MAs) are at higher risk of stroke; however, age- and sex-specific stroke incidence data are currently not available for this population. OBJECTIVE: This study was performed to compare the age-specific sex differences in stroke risk in MAs and NHWs. METHODS: Data were derived from the BASIC (Brain Attack Surveillance in Corpus Christi) Project, a population-based stroke surveillance study conducted in Nueces County Texas. Incident strokes (n = 2421, including ischemic stroke, intracerebral hemorrhage, and subarachnoid hemorrhage) that occurred between January 1, 2000 and May 25, 2007 in individuals aged 45 years or older were included in the analysis. Poisson regression using the generalized additive models framework was used to analyze the relationship between sex, age (5-year intervals), and race/ethnicity (NHW or MA) and incident stroke risk. RESULTS: Among both NHWs and MAs aged 45 to 79 years, men were at higher risk of stroke than women were. The magnitude of increased stroke risk in men compared with women diminished with age, and after age 79 years, no sex difference in stroke risk was observed. CONCLUSIONS: Reasons for the loss of protection from stroke in aging women of all races/ethnicities are not fully understood, and further study is warranted.
Authors: M Hollander; P J Koudstaal; M L Bots; D E Grobbee; A Hofman; M M B Breteler Journal: J Neurol Neurosurg Psychiatry Date: 2003-03 Impact factor: 10.154
Authors: James D Lewsey; Michelle Gillies; Pardeep S Jhund; Jim W T Chalmers; Adam Redpath; Andrew Briggs; Matthew Walters; Peter Langhorne; Simon Capewell; John J V McMurray; Kate Macintyre Journal: Stroke Date: 2009-02-10 Impact factor: 7.914
Authors: Paisith Piriyawat; Miriam Smajsová; Melinda A Smith; Sanjay Pallegar; Areej Al-Wabil; Nelda M Garcia; Jan M Risser; Lemuel A Moyé; Lewis B Morgenstern Journal: Am J Epidemiol Date: 2002-12-01 Impact factor: 4.897
Authors: Lewis B Morgenstern; Melinda A Smith; Lynda D Lisabeth; Jan M H Risser; Ken Uchino; Nelda Garcia; Paxton J Longwell; David A McFarling; Olubumi Akuwumi; Areej Al-Wabil; Fahmi Al-Senani; Devin L Brown; Lemuel A Moyé Journal: Am J Epidemiol Date: 2004-08-15 Impact factor: 4.897
Authors: Alan S Go; Dariush Mozaffarian; Véronique L Roger; Emelia J Benjamin; Jarett D Berry; Michael J Blaha; Shifan Dai; Earl S Ford; Caroline S Fox; Sheila Franco; Heather J Fullerton; Cathleen Gillespie; Susan M Hailpern; John A Heit; Virginia J Howard; Mark D Huffman; Suzanne E Judd; Brett M Kissela; Steven J Kittner; Daniel T Lackland; Judith H Lichtman; Lynda D Lisabeth; Rachel H Mackey; David J Magid; Gregory M Marcus; Ariane Marelli; David B Matchar; Darren K McGuire; Emile R Mohler; Claudia S Moy; Michael E Mussolino; Robert W Neumar; Graham Nichol; Dilip K Pandey; Nina P Paynter; Matthew J Reeves; Paul D Sorlie; Joel Stein; Amytis Towfighi; Tanya N Turan; Salim S Virani; Nathan D Wong; Daniel Woo; Melanie B Turner Journal: Circulation Date: 2013-12-18 Impact factor: 29.690
Authors: Emelia J Benjamin; Michael J Blaha; Stephanie E Chiuve; Mary Cushman; Sandeep R Das; Rajat Deo; Sarah D de Ferranti; James Floyd; Myriam Fornage; Cathleen Gillespie; Carmen R Isasi; Monik C Jiménez; Lori Chaffin Jordan; Suzanne E Judd; Daniel Lackland; Judith H Lichtman; Lynda Lisabeth; Simin Liu; Chris T Longenecker; Rachel H Mackey; Kunihiro Matsushita; Dariush Mozaffarian; Michael E Mussolino; Khurram Nasir; Robert W Neumar; Latha Palaniappan; Dilip K Pandey; Ravi R Thiagarajan; Mathew J Reeves; Matthew Ritchey; Carlos J Rodriguez; Gregory A Roth; Wayne D Rosamond; Comilla Sasson; Amytis Towfighi; Connie W Tsao; Melanie B Turner; Salim S Virani; Jenifer H Voeks; Joshua Z Willey; John T Wilkins; Jason Hy Wu; Heather M Alger; Sally S Wong; Paul Muntner Journal: Circulation Date: 2017-01-25 Impact factor: 29.690
Authors: Elizabeth R Stevens; Eric Roberts; Heather Carman Kuczynski; Bernadette Boden-Albala Journal: Value Health Date: 2019-07-27 Impact factor: 5.725
Authors: Alan S Go; Dariush Mozaffarian; Véronique L Roger; Emelia J Benjamin; Jarett D Berry; William B Borden; Dawn M Bravata; Shifan Dai; Earl S Ford; Caroline S Fox; Sheila Franco; Heather J Fullerton; Cathleen Gillespie; Susan M Hailpern; John A Heit; Virginia J Howard; Mark D Huffman; Brett M Kissela; Steven J Kittner; Daniel T Lackland; Judith H Lichtman; Lynda D Lisabeth; David Magid; Gregory M Marcus; Ariane Marelli; David B Matchar; Darren K McGuire; Emile R Mohler; Claudia S Moy; Michael E Mussolino; Graham Nichol; Nina P Paynter; Pamela J Schreiner; Paul D Sorlie; Joel Stein; Tanya N Turan; Salim S Virani; Nathan D Wong; Daniel Woo; Melanie B Turner Journal: Circulation Date: 2012-12-12 Impact factor: 29.690
Authors: Paola Gilsanz; Maria M Corrada; Claudia H Kawas; Elizabeth Rose Mayeda; M Maria Glymour; Charles P Quesenberry; Catherine Lee; Rachel A Whitmer Journal: Alzheimers Dement Date: 2019-02-20 Impact factor: 21.566
Authors: Elizabeth A Crago; Paula R Sherwood; Catherine Bender; Jeffrey Balzer; Dianxu Ren; Samuel M Poloyac Journal: Biol Res Nurs Date: 2014-12-29 Impact factor: 2.522
Authors: Virginia J Howard; Tracy E Madsen; Dawn O Kleindorfer; Suzanne E Judd; J David Rhodes; Elsayed Z Soliman; Brett M Kissela; Monika M Safford; Claudia S Moy; Leslie A McClure; George Howard; Mary Cushman Journal: JAMA Neurol Date: 2019-02-01 Impact factor: 18.302