| Literature DB >> 22445074 |
Hankui Wu1, Jun Li, Frank R Fronczek, Daneel Ferreira, Charles L Burandt, Vincent Setola, Bryan L Roth, Jordan K Zjawiony.
Abstract
Three known (leoleorins A-C) and eight hitherto unknown (leoleorins D-J and 16-epi-leoleorin F) labdane diterpenoids, were isolated from leaves of Leonotis leonurus. The absolute configurations of leoleorins A and D were established by X-ray crystallographic analyses. In a competitive binding assay, all isolated compounds showed inhibition in excess of 50% at various CNS receptors. Leoleorin C showed moderate binding affinity (Ki=2.9 μM) for the Sigma 1 receptor.Entities:
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Year: 2012 PMID： 22445074 PMCID： PMC3390464 DOI： 10.1016/j.phytochem.2012.02.021
Source DB: PubMed Journal: Phytochemistry ISSN： 0031-9422 Impact factor: 4.072