Xia Jiang1, Jiayi Dong, Bo Wang, Xuebin Yin, Liqiang Qin. 1. Department of Nutrition and Food Hygiene, School of Radiation Medicine and Public Health, Soochow University, Suzhou 215123, China. whojx@126.com
Abstract
OBJECTIVE: To study the effects of organic selenium supplementation on glutathione peroxidase (GPx) activities. METHODS: Randomized controlled trials (RCT) published from January 1988 to December 2010 on the relationship between organic selenium supplementation and GPx activities were collected. Meta-analysis was applied to estimate the combined standardized mean difference (SMD) and 95% confidence interval (95% CI). RESULTS: A total of 10 RCTs were included. The number of studies observing GPx activities in plasma, erythrocyte and platelet was 8, 5 and 5, respectively. Compared with the controls, the combined SMD (95% CI) of GPx activities in plasma, erythrocyte and platelet of subjects supplemented with organic selenium was 0.46 (0.09 - 0.83), 0.36 (0.02 - 0.69) and 0.56 (-0.02 - 1.15). CONCLUSION: Supplementation with organic selenium increases GPx activities in healthy adults.
OBJECTIVE: To study the effects of organic selenium supplementation on glutathione peroxidase (GPx) activities. METHODS: Randomized controlled trials (RCT) published from January 1988 to December 2010 on the relationship between organic selenium supplementation and GPx activities were collected. Meta-analysis was applied to estimate the combined standardized mean difference (SMD) and 95% confidence interval (95% CI). RESULTS: A total of 10 RCTs were included. The number of studies observing GPx activities in plasma, erythrocyte and platelet was 8, 5 and 5, respectively. Compared with the controls, the combined SMD (95% CI) of GPx activities in plasma, erythrocyte and platelet of subjects supplemented with organic selenium was 0.46 (0.09 - 0.83), 0.36 (0.02 - 0.69) and 0.56 (-0.02 - 1.15). CONCLUSION: Supplementation with organic selenium increases GPx activities in healthy adults.
Authors: Olga Parshukova; Natalya Potolitsyna; Vera Shadrina; Aleksei Chernykh; Evgeny Bojko Journal: Int Arch Occup Environ Health Date: 2013-07-31 Impact factor: 3.015