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Literature DB >> 22442486

Long-range-projecting GABAergic neurons modulate inhibition in hippocampus and entorhinal cortex.

Sarah Melzer¹, Magdalena Michael, Antonio Caputi, Marina Eliava, Elke C Fuchs, Miles A Whittington, Hannah Monyer.

Abstract

The hippocampus and entorhinal cortex play a pivotal role in spatial learning and memory. The two forebrain regions are highly interconnected via excitatory pathways. Using optogenetic tools, we identified and characterized long-range γ-aminobutyric acid-releasing (GABAergic) neurons that provide a bidirectional hippocampal-entorhinal inhibitory connectivity and preferentially target GABAergic interneurons. Activation of long-range GABAergic axons enhances sub- and suprathreshold rhythmic theta activity of postsynaptic neurons in the target areas.

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Substances：
Somatostatin

Year: 2012 PMID： 22442486 DOI： 10.1126/science.1217139

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

134 in total

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