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Literature DB >> 22441017

LRRK2 as a modulator of lysosomal calcium homeostasis with downstream effects on autophagy.

Abstract

Alterations in autophagy are thought to underlie various neurodegenerative diseases including Parkinson disease (PD). Previous studies have indicated that the PD gene leucine rich repeat kinase 2 (LRRK2) is involved in this process, but its mechanism of action has remained unknown. Our recent work describes how LRRK2 acts through calcium-mediated events originating from acidic stores to regulate autophagy and cell survival, which may give rise to novel therapeutic strategies.

Entities: Chemical Disease Gene

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Year: 2012 PMID： 22441017 DOI： 10.4161/auto.19305

Source DB: PubMed Journal: Autophagy ISSN： 1554-8627 Impact factor: 16.016

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Cited

15 in total

1. The Two-pore channel (TPC) interactome unmasks isoform-specific roles for TPCs in endolysosomal morphology and cell pigmentation.

Authors: Yaping Lin-Moshier; Michael V Keebler; Robert Hooper; Michael J Boulware; Xiaolong Liu; Dev Churamani; Mary E Abood; Timothy F Walseth; Eugen Brailoiu; Sandip Patel; Jonathan S Marchant
Journal: Proc Natl Acad Sci U S A Date: 2014-08-25 Impact factor: 11.205

2. WHOPPA Enables Parallel Assessment of Leucine-Rich Repeat Kinase 2 and Glucocerebrosidase Enzymatic Activity in Parkinson's Disease Monocytes.

Authors: Rebecca L Wallings; Laura P Hughes; Hannah A Staley; Zachary D Simon; Nikolaus R McFarland; Roy N Alcalay; Alicia Garrido; María José Martí; Eduardo Tolosa Sarró; Nicolas Dzamko; Malú Gámez Tansey
Journal: Front Cell Neurosci Date: 2022-06-09 Impact factor: 6.147

3. Genotype and age at Parkinson disease diagnosis.

Authors: Susan Searles Nielsen; Theo K Bammler; Lisa G Gallagher; Federico M Farin; Wt Longstreth; Gary M Franklin; Phillip D Swanson; Harvey Checkoway
Journal: Int J Mol Epidemiol Genet Date: 2013-03-18

Review 4. Aberrant autophagy and parkinsonism: does correction rescue from disease progression?

Authors: Abhishek Kumar Mishra; Mohd Sami ur Rasheed; Saurabh Shukla; Manish Kumar Tripathi; Anubhuti Dixit; Mahendra Pratap Singh
Journal: Mol Neurobiol Date: 2014-05-16 Impact factor: 5.590

5. The LRRK2 inhibitor GSK2578215A induces protective autophagy in SH-SY5Y cells: involvement of Drp-1-mediated mitochondrial fission and mitochondrial-derived ROS signaling.

Authors: S Saez-Atienzar; L Bonet-Ponce; J R Blesa; F J Romero; M P Murphy; J Jordan; M F Galindo
Journal: Cell Death Dis Date: 2014-08-14 Impact factor: 8.469

LRRK2 as a modulator of lysosomal calcium homeostasis with downstream effects on autophagy.

1. The Two-pore channel (TPC) interactome unmasks isoform-specific roles for TPCs in endolysosomal morphology and cell pigmentation.

2. WHOPPA Enables Parallel Assessment of Leucine-Rich Repeat Kinase 2 and Glucocerebrosidase Enzymatic Activity in Parkinson's Disease Monocytes.

3. Genotype and age at Parkinson disease diagnosis.

Review 4. Aberrant autophagy and parkinsonism: does correction rescue from disease progression?

5. The LRRK2 inhibitor GSK2578215A induces protective autophagy in SH-SY5Y cells: involvement of Drp-1-mediated mitochondrial fission and mitochondrial-derived ROS signaling.

Review 6. The role of the LRRK2 gene in Parkinsonism.

Review 7. The role of Ca²⁺ signaling in Parkinson's disease.

8. A Link between Autophagy and the Pathophysiology of LRRK2 in Parkinson's Disease.

9. Surfactant secretion in LRRK2 knock-out rats: changes in lamellar body morphology and rate of exocytosis.

Review 10. Mitochondria: A Therapeutic Target for Parkinson's Disease?

LRRK2 as a modulator of lysosomal calcium homeostasis with downstream effects on autophagy.

1. The Two-pore channel (TPC) interactome unmasks isoform-specific roles for TPCs in endolysosomal morphology and cell pigmentation.

2. WHOPPA Enables Parallel Assessment of Leucine-Rich Repeat Kinase 2 and Glucocerebrosidase Enzymatic Activity in Parkinson's Disease Monocytes.

3. Genotype and age at Parkinson disease diagnosis.

Review 4. Aberrant autophagy and parkinsonism: does correction rescue from disease progression?

5. The LRRK2 inhibitor GSK2578215A induces protective autophagy in SH-SY5Y cells: involvement of Drp-1-mediated mitochondrial fission and mitochondrial-derived ROS signaling.

Review 6. The role of the LRRK2 gene in Parkinsonism.

Review 7. The role of Ca2+ signaling in Parkinson's disease.

8. A Link between Autophagy and the Pathophysiology of LRRK2 in Parkinson's Disease.

9. Surfactant secretion in LRRK2 knock-out rats: changes in lamellar body morphology and rate of exocytosis.

Review 10. Mitochondria: A Therapeutic Target for Parkinson's Disease?

Review 7. The role of Ca²⁺ signaling in Parkinson's disease.