OBJECTIVE: To examine the effect of 50,000 IU-vitamin D₂ supplementation in a clinical setting on serum total 25-hydroxyvitamin D (25[OH]D), 25-hydroxyvitamin D₂ (25[OH]D₂), and 25-hydroxyvitamin D3 (25[OH]D₃). METHODS: This retrospective cohort study was performed in an urban tertiary referral hospital in Boston, Massachusetts. Patients who had been prescribed 50,000 IU vitamin D₂ repletion and maintenance programs were identified through a search of our electronic medical record. Baseline and follow-up total serum 25(OH)D, 25(OH)D₂, and 25(OH)D₃ levels were compared. RESULTS: We examined the medical records of 48 patients who had been prescribed 50,000 IU vitamin D₂ in our clinic. Mean ± standard deviation baseline total 25(OH)D was 31.0 ± 10.6 ng/mL and rose to 48.3 ± 13.4 ng/mL after treatment (P<.001). 25(OH)D₂ increased from 4.2 ± 4.3 ng/mL to 34.6 ± 12.3 ng/mL after treatment (P<.001), for an average of 158 days (range, 35-735 days). Serum 25(OH)D₃ decreased from 26.8 ± 10.8 ng/mL to 13.7 ± 7.9 ng/mL (P<.001). CONCLUSIONS: Fifty thousand IU vitamin D₂ repletion and maintenance therapy substantially increases total 25(OH)D and 25(OH)D₂ despite a decrease in serum 25(OH)D₃. This treatment program is an appropriate and effective strategy to treat and prevent vitamin D deficiency.
OBJECTIVE: To examine the effect of 50,000 IU-vitamin D₂ supplementation in a clinical setting on serum total 25-hydroxyvitamin D (25[OH]D), 25-hydroxyvitamin D₂ (25[OH]D₂), and 25-hydroxyvitamin D3 (25[OH]D₃). METHODS: This retrospective cohort study was performed in an urban tertiary referral hospital in Boston, Massachusetts. Patients who had been prescribed 50,000 IU vitamin D₂ repletion and maintenance programs were identified through a search of our electronic medical record. Baseline and follow-up total serum 25(OH)D, 25(OH)D₂, and 25(OH)D₃ levels were compared. RESULTS: We examined the medical records of 48 patients who had been prescribed 50,000 IU vitamin D₂ in our clinic. Mean ± standard deviation baseline total 25(OH)D was 31.0 ± 10.6 ng/mL and rose to 48.3 ± 13.4 ng/mL after treatment (P<.001). 25(OH)D₂ increased from 4.2 ± 4.3 ng/mL to 34.6 ± 12.3 ng/mL after treatment (P<.001), for an average of 158 days (range, 35-735 days). Serum 25(OH)D₃ decreased from 26.8 ± 10.8 ng/mL to 13.7 ± 7.9 ng/mL (P<.001). CONCLUSIONS: Fifty thousand IU vitamin D₂ repletion and maintenance therapy substantially increases total 25(OH)D and 25(OH)D₂ despite a decrease in serum 25(OH)D₃. This treatment program is an appropriate and effective strategy to treat and prevent vitamin D deficiency.
Authors: Christine M Swanson; Carrie M Nielson; Smriti Shrestha; Christine G Lee; Elizabeth Barrett-Connor; Ivo Jans; Jane A Cauley; Steven Boonen; Roger Bouillon; Dirk Vanderschueren; Eric S Orwoll Journal: J Clin Endocrinol Metab Date: 2014-05-14 Impact factor: 5.958
Authors: William B Grant; Sunil J Wimalawansa; Michael F Holick; John J Cannell; Pawel Pludowski; Joan M Lappe; Mary Pittaway; Philip May Journal: Nutrients Date: 2015-02-27 Impact factor: 5.717
Authors: Emily C Sanders; Robert M Burkes; Jason R Mock; Todd T Brown; Robert A Wise; Nadia N Hansel; Mark C Liu; M Bradley Drummond Journal: Chronic Obstr Pulm Dis Date: 2021-07-28
Authors: K S Jones; S Assar; D Harnpanich; R Bouillon; D Lambrechts; A Prentice; I Schoenmakers Journal: J Clin Endocrinol Metab Date: 2014-06-02 Impact factor: 5.958