Literature DB >> 22440782

Selected approaches for increasing HIV DNA vaccine immunogenicity in vivo.

Natalie A Hutnick1, Devin J F Myles, Chaoran Billie Bian, Karuppiah Muthumani, David B Weiner.   

Abstract

The safety, stability, and ability for repeat homologous vaccination makes the DNA vaccine platform an excellent candidate for an effective HIV-1 vaccine. However, the immunogenicity of early DNA vaccines did not translate from small animal models into larger non-human primates and was markedly lower than viral vectors. In addition to improvements to the DNA vector itself, delivery with electroporation, the inclusion of molecular adjuvants, and heterologous prime-boost strategies have dramatically improved the immunogenicity of DNA vaccines for HIV and currently makes them a leading platform with many areas warranting further research and clinical development.
Copyright © 2011 Elsevier B.V. All rights reserved.

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Year:  2011        PMID： 22440782      PMCID： PMC3725312          DOI： 10.1016/j.coviro.2011.08.003

Source DB:  PubMed          Journal:  Curr Opin Virol        ISSN： 1879-6257            Impact factor:   7.090


  52 in total

1.  Comparative ability of plasmid IL-12 and IL-15 to enhance cellular and humoral immune responses elicited by a SIVgag plasmid DNA vaccine and alter disease progression following SHIV(89.6P) challenge in rhesus macaques.

Authors:  Siew-Yen Chong; Michael A Egan; Michele A Kutzler; Shakuntala Megati; Amjed Masood; Vidia Roopchard; Dorys Garcia-Hand; David C Montefiori; Jorge Quiroz; Margherita Rosati; Eva B Schadeck; Jean D Boyer; George N Pavlakis; David B Weiner; Maninder Sidhu; John H Eldridge; Zimra R Israel
Journal:  Vaccine       Date:  2007-02-14       Impact factor: 3.641

2.  Combined effects of IL-12 and electroporation enhances the potency of DNA vaccination in macaques.

Authors:  Lauren A Hirao; Ling Wu; Amir S Khan; David A Hokey; Jian Yan; Anlan Dai; Michael R Betts; Ruxandra Draghia-Akli; David B Weiner
Journal:  Vaccine       Date:  2008-03-11       Impact factor: 3.641

3.  DNA-based immunization by in vivo transfection of dendritic cells.

Authors:  C Condon; S C Watkins; C M Celluzzi; K Thompson; L D Falo
Journal:  Nat Med       Date:  1996-10       Impact factor: 53.440

4.  Effect of plasmid DNA vaccine design and in vivo electroporation on the resulting vaccine-specific immune responses in rhesus macaques.

Authors:  Amara Luckay; Maninder K Sidhu; Rune Kjeken; Shakuntala Megati; Siew-Yen Chong; Vidia Roopchand; Dorys Garcia-Hand; Rashed Abdullah; Ralph Braun; David C Montefiori; Margherita Rosati; Barbara K Felber; George N Pavlakis; Iacob Mathiesen; Zimra R Israel; John H Eldridge; Michael A Egan
Journal:  J Virol       Date:  2007-02-28       Impact factor: 5.103

5.  Manipulation of the immune response to a plasmid-encoded viral antigen by coinoculation with plasmids expressing cytokines.

Authors:  Z Xiang; H C Ertl
Journal:  Immunity       Date:  1995-02       Impact factor: 31.745

6.  Safety and immunogenicity of a replication-incompetent adenovirus type 5 HIV-1 clade B gag/pol/nef vaccine in healthy adults.

Authors:  Frances H Priddy; Deborah Brown; James Kublin; Kathleen Monahan; David P Wright; Jacob Lalezari; Steven Santiago; Michael Marmor; Michelle Lally; Richard M Novak; Stephen J Brown; Priya Kulkarni; Sheri A Dubey; Lisa S Kierstead; Danilo R Casimiro; Robin Mogg; Mark J DiNubile; John W Shiver; Randi Y Leavitt; Michael N Robertson; Devan V Mehrotra; Erin Quirk
Journal:  Clin Infect Dis       Date:  2008-06-01       Impact factor: 9.079

7.  Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial.

Authors:  Susan P Buchbinder; Devan V Mehrotra; Ann Duerr; Daniel W Fitzgerald; Robin Mogg; David Li; Peter B Gilbert; Javier R Lama; Michael Marmor; Carlos Del Rio; M Juliana McElrath; Danilo R Casimiro; Keith M Gottesdiener; Jeffrey A Chodakewitz; Lawrence Corey; Michael N Robertson
Journal:  Lancet       Date:  2008-11-13       Impact factor: 79.321

8.  Cross-subtype antibody and cellular immune responses induced by a polyvalent DNA prime-protein boost HIV-1 vaccine in healthy human volunteers.

Authors:  Shixia Wang; Jeffrey S Kennedy; Kim West; David C Montefiori; Scott Coley; John Lawrence; Siyuan Shen; Sharone Green; Alan L Rothman; Francis A Ennis; James Arthos; Ranajit Pal; Phillip Markham; Shan Lu
Journal:  Vaccine       Date:  2008-07-23       Impact factor: 3.641

9.  Intradermal/subcutaneous immunization by electroporation improves plasmid vaccine delivery and potency in pigs and rhesus macaques.

Authors:  Lauren A Hirao; Ling Wu; Amir S Khan; Abhishek Satishchandran; Ruxandra Draghia-Akli; David B Weiner
Journal:  Vaccine       Date:  2007-11-08       Impact factor: 3.641

10.  Chimpanzee adenovirus antibodies in humans, sub-Saharan Africa.

Authors:  Zhiquan Xiang; Yan Li; Ann Cun; Wei Yang; Susan Ellenberg; William M Switzer; Marcia L Kalish; Hildegund C J Ertl
Journal:  Emerg Infect Dis       Date:  2006-10       Impact factor: 6.883
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  36 in total

1.  Skin Transfection Patterns and Expression Kinetics of Electroporation-Enhanced Plasmid Delivery Using the CELLECTRA-3P, a Portable Next-Generation Dermal Electroporation Device.

Authors:  Dinah H Amante; Trevor R F Smith; Janess M Mendoza; Katherine Schultheis; Jay R McCoy; Amir S Khan; Niranjan Y Sardesai; Kate E Broderick
Journal:  Hum Gene Ther Methods       Date:  2015-08       Impact factor: 2.396

2.  Comparison of intradermal and intramuscular delivery followed by in vivo electroporation of SIV Env DNA in macaques.

Authors:  Viraj Kulkarni; Margherita Rosati; Jenifer Bear; Guy R Pilkington; Rashmi Jalah; Cristina Bergamaschi; Ashish K Singh; Candido Alicea; Bhabadeb Chowdhury; Gen-Mu Zhang; Eun-Young Kim; Steven M Wolinsky; Wensheng Huang; Yongjun Guan; Celia LaBranche; David C Montefiori; Kate E Broderick; Niranjan Y Sardesai; Antonio Valentin; Barbara K Felber; George N Pavlakis
Journal:  Hum Vaccin Immunother       Date:  2013-06-28       Impact factor: 3.452

3.  IL-12 DNA as molecular vaccine adjuvant increases the cytotoxic T cell responses and breadth of humoral immune responses in SIV DNA vaccinated macaques.

Authors:  Rashmi Jalah; Vainav Patel; Viraj Kulkarni; Margherita Rosati; Candido Alicea; Brunda Ganneru; Agneta von Gegerfelt; Wensheng Huang; Yongjun Guan; Kate E Broderick; Niranjan Y Sardesai; Celia LaBranche; David C Montefiori; George N Pavlakis; Barbara K Felber
Journal:  Hum Vaccin Immunother       Date:  2012-08-16       Impact factor: 3.452

Review 4.  New developments in an old strategy: heterologous vector primes and envelope protein boosts in HIV vaccine design.

Authors:  Thomas Musich; Marjorie Robert-Guroff
Journal:  Expert Rev Vaccines       Date:  2016-03-16       Impact factor: 5.217

Review 5.  DNA vaccines: roles against diseases.

Authors:  Kishwar Hayat Khan
Journal:  Germs       Date:  2013-03-01

6.  Innate Molecular and Cellular Signature in the Skin Preceding Long-Lasting T Cell Responses after Electroporated DNA Vaccination.

Authors:  Lucille Adam; Nicolas Tchitchek; Biliana Todorova; Pierre Rosenbaum; Candie Joly; Candice Poux; Catherine Chapon; Anna-Lena Spetz; Mart Ustav; Roger Le Grand; Frédéric Martinon
Journal:  J Immunol       Date:  2020-05-08       Impact factor: 5.422

7.  HIV/SIV DNA vaccine combined with protein in a co-immunization protocol elicits highest humoral responses to envelope in mice and macaques.

Authors:  Jinyao Li; Antonio Valentin; Viraj Kulkarni; Margherita Rosati; Rachel Kelly Beach; Candido Alicea; Drew Hannaman; Steven G Reed; Barbara K Felber; George N Pavlakis
Journal:  Vaccine       Date:  2013-04-26       Impact factor: 3.641

8.  Vaccination with Vaxfectin(®) adjuvanted SIV DNA induces long-lasting humoral immune responses able to reduce SIVmac251 Viremia.

Authors:  Viraj Kulkarni; Margherita Rosati; Antonio Valentin; Rashmi Jalah; Candido Alicea; Lei Yu; Yongjun Guan; Xiaoying Shen; Georgia D Tomaras; Celia LaBranche; David C Montefiori; Carmela Irene; Rajasekhar Prattipati; Abraham Pinter; Sean M Sullivan; George N Pavlakis; Barbara K Felber
Journal:  Hum Vaccin Immunother       Date:  2013-07-02       Impact factor: 3.452

9.  DNA and virus particle vaccination protects against acquisition and confers control of viremia upon heterologous simian immunodeficiency virus challenge.

Authors:  Vainav Patel; Rashmi Jalah; Viraj Kulkarni; Antonio Valentin; Margherita Rosati; Candido Alicea; Agneta von Gegerfelt; Wensheng Huang; Yongjun Guan; Brandon F Keele; Julian W Bess; Michael Piatak; Jeffrey D Lifson; William T Williams; Xiaoying Shen; Georgia D Tomaras; Rama R Amara; Harriet L Robinson; Welkin Johnson; Kate E Broderick; Niranjan Y Sardesai; David J Venzon; Vanessa M Hirsch; Barbara K Felber; George N Pavlakis
Journal:  Proc Natl Acad Sci U S A       Date:  2013-01-28       Impact factor: 11.205

10.  Safety and immunogenicity of DNA prime and modified vaccinia ankara virus-HIV subtype C vaccine boost in healthy adults.

Authors:  Peter Hayes; Jill Gilmour; Andrea von Lieven; Dilbinder Gill; Lorna Clark; Jakub Kopycinski; Hannah Cheeseman; Amy Chung; Galit Alter; Len Dally; Devika Zachariah; Angela Lombardo; James Ackland; Eddy Sayeed; Akil Jackson; Marta Boffito; Brian Gazzard; Patricia E Fast; Josephine H Cox; Dagna Laufer
Journal:  Clin Vaccine Immunol       Date:  2013-01-23
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