BACKGROUND: a direct association between visceral adiposity on abdominal computed tomography (CT) and cognitive performance has not been reported. OBJECTIVES: to investigate the associations between total and regional adiposity measured with abdominal CT, and cognitive performance in elderly persons and to explore their modification by age. DESIGN: cross-sectional study. SETTING: a health promotion centre of a tertiary university hospital. SUBJECTS: two-hundred and fifty individuals aged 60 years and above who underwent anthropometric measurements, abdominal CT and cognitive testing. METHODS: adiposity measures included body mass index (BMI), waist circumference and visceral and subcutaneous adiposity by abdominal CT. Poor cognitive performance was defined as Mini-Mental State Examination score being at or below 1 SD of age, sex and education-normative values. RESULTS: in multivariate logistic regression analyses obesity [odds ratio (OR) 2.61, 95% confidence interval (CI)=1.21-6.01, P=0.015] and being in the top tertile of the visceral adiposity area (OR: 2.58, 95% CI=1.001-6.62, P=0.045) were associated with poor cognitive performance in subjects younger than 70 years, but not in those 70 years and older. CONCLUSION: high adiposity, particularly visceral adiposity, was associated with poor cognitive functioning in younger elderly persons.
BACKGROUND: a direct association between visceral adiposity on abdominal computed tomography (CT) and cognitive performance has not been reported. OBJECTIVES: to investigate the associations between total and regional adiposity measured with abdominal CT, and cognitive performance in elderly persons and to explore their modification by age. DESIGN: cross-sectional study. SETTING: a health promotion centre of a tertiary university hospital. SUBJECTS: two-hundred and fifty individuals aged 60 years and above who underwent anthropometric measurements, abdominal CT and cognitive testing. METHODS: adiposity measures included body mass index (BMI), waist circumference and visceral and subcutaneous adiposity by abdominal CT. Poor cognitive performance was defined as Mini-Mental State Examination score being at or below 1 SD of age, sex and education-normative values. RESULTS: in multivariate logistic regression analyses obesity [odds ratio (OR) 2.61, 95% confidence interval (CI)=1.21-6.01, P=0.015] and being in the top tertile of the visceral adiposity area (OR: 2.58, 95% CI=1.001-6.62, P=0.045) were associated with poor cognitive performance in subjects younger than 70 years, but not in those 70 years and older. CONCLUSION: high adiposity, particularly visceral adiposity, was associated with poor cognitive functioning in younger elderly persons.
Authors: Kirby G Parker; Seth T Lirette; David S Deardorff; Lawrence F Bielak; Patricia A Peyser; J Jeffrey Carr; James G Terry; Myriam Fornage; Emelia J Benjamin; Stephen T Turner; Thomas H Mosley; Michael E Griswold; B Gwen Windham Journal: J Gerontol A Biol Sci Med Sci Date: 2018-03-14 Impact factor: 6.053
Authors: Mark Mapstone; Tiffany N Hilton; Hongmei Yang; Joseph J Guido; Amneris E Luque; William J Hall; Stephen Dewhurst; Krupa Shah Journal: Aging Dis Date: 2013-08-27 Impact factor: 6.745
Authors: Elizabeth Dao; Jennifer C Davis; Devika Sharma; Alison Chan; Lindsay S Nagamatsu; Teresa Liu-Ambrose Journal: PLoS One Date: 2013-01-07 Impact factor: 3.240