BACKGROUND: We conducted this study to investigate whether formalin fixation is associated with the shrinkage of head and neck cancer specimens. METHODS: Patients scheduled to undergo operation were eligible for enrollment. Fresh specimens were measured immediately in the operating room, and the measurements were repeated after formalin fixation. RESULTS: A total of 100 specimens were collected. Nearly half of them were obtained from the oral cavity (n=49), and a large majority were squamous cell carcinoma (n=69). The average decreases in length, width, and depth after formalin fixation were 1.50mm (4.40%), 1.52 mm (6.18%), and 0.67 mm (4.10%), respectively. There was no significant difference in the shrinkage percentage associated with gender, age, tumor site, tumor size, or histology. CONCLUSION: We found that head and neck cancer specimens shrink after formalin fixation. Therefore, we recommend that the specimen be measured immediately in order to avoid the underestimation of tumor size. Copyright Â
BACKGROUND: We conducted this study to investigate whether formalin fixation is associated with the shrinkage of head and neck cancer specimens. METHODS:Patients scheduled to undergo operation were eligible for enrollment. Fresh specimens were measured immediately in the operating room, and the measurements were repeated after formalin fixation. RESULTS: A total of 100 specimens were collected. Nearly half of them were obtained from the oral cavity (n=49), and a large majority were squamous cell carcinoma (n=69). The average decreases in length, width, and depth after formalin fixation were 1.50mm (4.40%), 1.52 mm (6.18%), and 0.67 mm (4.10%), respectively. There was no significant difference in the shrinkage percentage associated with gender, age, tumor site, tumor size, or histology. CONCLUSION: We found that head and neck cancer specimens shrink after formalin fixation. Therefore, we recommend that the specimen be measured immediately in order to avoid the underestimation of tumor size. Copyright Â
Authors: Aiden O'Grady; Luke Welsh; Matthew Gibson; James Briggs; Archie Speirs; Mark Little Journal: Cardiovasc Intervent Radiol Date: 2021-10-17 Impact factor: 2.740
Authors: G Tirelli; S Zacchigna; F Boscolo Nata; E Quatela; R Di Lenarda; M Piovesana Journal: Eur Arch Otorhinolaryngol Date: 2016-08-04 Impact factor: 2.503
Authors: Tri Huynh; Karla Ali; Shraddha Vyas; Kaleena Dezsi; Destiny Strickland; Toni Basinski; Dung-Tsa Chen; Kun Jiang; Barbara Centeno; Mokenge Malafa; Jason B Klapman; Pamela J Hodul; Daniel Jeong; Jennifer B Permuth Journal: Pancreatology Date: 2020-02-21 Impact factor: 3.996