| Literature DB >> 22440113 |
Shi-Chao Cui1, Jie Yu, Xiao-Hui Zhang, Mei-Zhen Cheng, La-Wei Yang, Jing-Yan Xu.
Abstract
The hypoglycemic and antioxidant effects of the water extract from Anoectochilus roxburghii in alloxan-induced diabetic mice were examined. Compared with untreated diabetic mice, the daily oral administration of the water extract from A. roxburghii at 0.5 or 2 g/kg for 14 days caused a significant decrease (p<.05) in blood glucose levels with similar effect but no evidence of dose-related effect. Simultaneously, the alteration in lipid metabolism was partially attenuated as evidenced by decreased serum total cholesterol and triglyceride levels and by increased high-density lipoprotein cholesterol concentration in diabetic mice (p<.05) but no dose-related effect was observed. In addition, the water extract from A. roxburghii caused a significant increase (p<.05) in the activities of enzymic antioxidants and the levels of vitamin E in liver and kidney of diabetic mice. Our results suggest that water extract from A. roxburghii possesses hypoglycemic and antioxidant properties after oral administration to mice showing alloxan-induced diabetes.Entities:
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Year: 2012 PMID： 22440113 DOI： 10.1016/j.etp.2012.02.003
Source DB: PubMed Journal: Exp Toxicol Pathol ISSN： 0940-2993