AIM: The aim of this study was to evaluate the association of urinary tubular markers, interleukin-18 (IL-18) and angiotensinogen with albuminuria in early nephropathy of type 2 diabetics. METHODS: Urine levels of tubular markers (kidney injury molecule [KIM]-1, neutrophil gelatinase-associated lipocalin [NGAL] and liver-type fatty acid-binding protein [L-FABP]), proinflammatory marker (IL-18), and a marker of intrarenal renin-angiotensin system (RAS) status (angiotensinogen) were determined in 118 patients with type 2 diabetes mellitus and 25 non-diabetic controls with estimated glomerular filtration rate (eGFR) ≥ 60 mL/min/1.73 m(2). RESULTS: Urinary levels of KIM-1, NGAL, IL-18 and angiotensinogen were significantly higher in macroalbuminuria group compared with control and normo- and microalbuminuria groups but not significantly different between control and normoalbuminuria group. Urinary tubular markers were positively correlated with urinary IL-18 and angiotensinogen, respectively. The urinary albuminuria was correlated with all investigated urinary markers in univariate analysis. After adjusting for several clinical parameters, urinary KIM-1, NGAL and angiotensinogen were significantly associated with albuminuria. CONCLUSIONS: The results of this study suggest that urinary tubular markers may be independently associated with albuminuria in the early stage of nephropathy in type 2 diabetics (eGFR ≥ 60 mL/min/1.73 m(2)) and may reflect inflammatory processing and the activation of the intrarenal RAS.
AIM: The aim of this study was to evaluate the association of urinary tubular markers, interleukin-18 (IL-18) and angiotensinogen with albuminuria in early nephropathy of type 2 diabetics. METHODS: Urine levels of tubular markers (kidney injury molecule [KIM]-1, neutrophil gelatinase-associated lipocalin [NGAL] and liver-type fatty acid-binding protein [L-FABP]), proinflammatory marker (IL-18), and a marker of intrarenal renin-angiotensin system (RAS) status (angiotensinogen) were determined in 118 patients with type 2 diabetes mellitus and 25 non-diabetic controls with estimated glomerular filtration rate (eGFR) ≥ 60 mL/min/1.73 m(2). RESULTS: Urinary levels of KIM-1, NGAL, IL-18 and angiotensinogen were significantly higher in macroalbuminuria group compared with control and normo- and microalbuminuria groups but not significantly different between control and normoalbuminuria group. Urinary tubular markers were positively correlated with urinary IL-18 and angiotensinogen, respectively. The urinary albuminuria was correlated with all investigated urinary markers in univariate analysis. After adjusting for several clinical parameters, urinary KIM-1, NGAL and angiotensinogen were significantly associated with albuminuria. CONCLUSIONS: The results of this study suggest that urinary tubular markers may be independently associated with albuminuria in the early stage of nephropathy in type 2 diabetics (eGFR ≥ 60 mL/min/1.73 m(2)) and may reflect inflammatory processing and the activation of the intrarenal RAS.
Authors: Gudeta D Fufaa; E Jennifer Weil; Robert G Nelson; Robert L Hanson; Joseph V Bonventre; Venkata Sabbisetti; Sushrut S Waikar; Theodore E Mifflin; Xiaoming Zhang; Dawei Xie; Chi-Yuan Hsu; Harold I Feldman; Josef Coresh; Ramachandran S Vasan; Paul L Kimmel; Kathleen D Liu Journal: Diabetologia Date: 2014-10-15 Impact factor: 10.122
Authors: Jan Wysocki; Anne Goodling; Mar Burgaya; Kathryn Whitlock; John Ruzinski; Daniel Batlle; Maryam Afkarian Journal: Am J Physiol Renal Physiol Date: 2017-05-03
Authors: Sang Soo Kim; Sang Heon Song; Jong Ho Kim; Yun Kyung Jeon; Bo Hyun Kim; Min-Cheol Kang; Sung Wan Chun; Soo Hyun Hong; Michelle Chung; Yong Ki Kim; In Joo Kim; Young-Bum Kim Journal: Clin Endocrinol (Oxf) Date: 2017-05-22 Impact factor: 3.478
Authors: Maryam Afkarian; Leila R Zelnick; John Ruzinski; Bryan Kestenbaum; Jonathan Himmelfarb; Ian H de Boer; Rajnish Mehrotra Journal: J Diabetes Complications Date: 2015-09-02 Impact factor: 2.852