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Literature DB >> 22439928

ALK and MYCN: when two oncogenes are better than one.

Abstract

Mutations of ALK are frequently observed in MYCN-amplified neuroblastomas and correlate with poor clinical outcome, but how these oncogenes cooperate in neuroblastoma development remains unclear. In this issue of Cancer Cell, Zhu et al. describe a mechanism by which ALK and MYCN synergistically induce neuroblastoma in the zebrafish model system. Copyright Â

Entities: CellLine Chemical Disease Gene Mutation Species

Year: 2012 PMID： 22439928 PMCID： PMC3322412 DOI： 10.1016/j.ccr.2012.03.004

Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743

10 in total

Review 1. Emerging importance of ALK in neuroblastoma.

Authors: Anna M Azarova; Gargi Gautam; Rani E George
Journal: Semin Cancer Biol Date: 2011-09-16 Impact factor: 15.707

2. Targeting MYC dependence in cancer by inhibiting BET bromodomains.

Authors: Jennifer A Mertz; Andrew R Conery; Barbara M Bryant; Peter Sandy; Srividya Balasubramanian; Deanna A Mele; Louise Bergeron; Robert J Sims
Journal: Proc Natl Acad Sci U S A Date: 2011-09-26 Impact factor: 11.205

3. Anaplastic Lymphoma Kinase (ALK) regulates initiation of transcription of MYCN in neuroblastoma cells.

Authors: C Schönherr; K Ruuth; S Kamaraj; C-L Wang; H-L Yang; V Combaret; A Djos; T Martinsson; J G Christensen; R H Palmer; B Hallberg
Journal: Oncogene Date: 2012-01-30 Impact factor: 9.867

4. EZH2 Mediates epigenetic silencing of neuroblastoma suppressor genes CASZ1, CLU, RUNX3, and NGFR.

Authors: Chunxi Wang; Zhihui Liu; Chan-Wook Woo; Zhijie Li; Lifeng Wang; Jun S Wei; Victor E Marquez; Susan E Bates; Qihuang Jin; Javed Khan; Kai Ge; Carol J Thiele
Journal: Cancer Res Date: 2011-11-08 Impact factor: 12.701

5. Activated ALK collaborates with MYCN in neuroblastoma pathogenesis.

Authors: Shizhen Zhu; Jeong-Soo Lee; Feng Guo; Jimann Shin; Antonio R Perez-Atayde; Jeffery L Kutok; Scott J Rodig; Donna S Neuberg; Daniel Helman; Hui Feng; Rodney A Stewart; Wenchao Wang; Rani E George; John P Kanki; A Thomas Look
Journal: Cancer Cell Date: 2012-03-20 Impact factor: 31.743

6. PI3King on MYCN to improve neuroblastoma therapeutics.

Authors: Michael D Hogarty; John M Maris
Journal: Cancer Cell Date: 2012-02-14 Impact factor: 31.743

7. Myc regulates the transcription of the PRC2 gene to control the expression of developmental genes in embryonic stem cells.

Authors: Francesco Neri; Alessio Zippo; Anna Krepelova; Alessandro Cherubini; Marina Rocchigiani; Salvatore Oliviero
Journal: Mol Cell Biol Date: 2011-12-19 Impact factor: 4.272

8. Targeted expression of MYCN causes neuroblastoma in transgenic mice.

Authors: W A Weiss; K Aldape; G Mohapatra; B G Feuerstein; J M Bishop
Journal: EMBO J Date: 1997-06-02 Impact factor: 11.598

Review 9. Recent advances in neuroblastoma.

Authors: John M Maris
Journal: N Engl J Med Date: 2010-06-10 Impact factor: 91.245

10. Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma.

Authors: S W Morris; M N Kirstein; M B Valentine; K G Dittmer; D N Shapiro; D L Saltman; A T Look
Journal: Science Date: 1994-03-04 Impact factor: 47.728

10 in total

3 in total

1. An overview of neuroblastoma cell lineage phenotypes and in vitro models.

Authors: Sheron Campos Cogo; Thatyanne Gradowski Farias da Costa do Nascimento; Fernanda de Almeida Brehm Pinhatti; Nilton de França Junior; Bruna Santos Rodrigues; Luciane Regina Cavalli; Selene Elifio-Esposito
Journal: Exp Biol Med (Maywood) Date: 2020-08-12

Review 2. Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology.

Authors: Bengt Hallberg; Ruth H Palmer
Journal: Nat Rev Cancer Date: 2013-10 Impact factor: 60.716

3. Low Frequency ALK Hotspots Mutations In Neuroblastoma Tumours Detected By Ultra-deep Sequencing: Implications For ALK Inhibitor Treatment.

Authors: Niloufar Javanmardi; Susanne Fransson; Anna Djos; Rose-Marie Sjöberg; Staffan Nilsson; Katarina Truvé; Per Kogner; Tommy Martinsson
Journal: Sci Rep Date: 2019-02-18 Impact factor: 4.379

3 in total