| Literature DB >> 22439897 |
Wei Bi1, Xiaoxu Li, Yue Bi, Ping Xue, Yanrong Zhang, Xiang Gao, Zhibo Wang, Meng Li, Yasuhiro Itagaki, Lanrong Bi.
Abstract
We have recently developed new Tempo-PEG-RGDs conjugates and have quantitatively examined their antithrombotic and antioxidant capabilities. These compounds were therapeutically beneficial when characterized in both in vitro platelet aggregation assays and a rat model of arterial thrombosis. Moreover, these compounds demonstrated significant protection from organ damage in a rat model of ischemia/reperfusion. Our data indicate that Tempo-PEG-RGDs represent a new class of adjuvants with therapeutic efficacy in acute and transient ischemic damage.Entities:
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Year: 2012 PMID： 22439897 DOI： 10.1021/jm201381w
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446