Literature DB >> 2243683

Scatter photocoagulation restores tissue hypoxia in experimental vasoproliferative microangiopathy in miniature pigs.

C J Pournaras1, M Tsacopoulos, K Strommer, N Gilodi, P M Leuenberger.   

Abstract

Experimental retinal branch vein occlusion using argon laser photocoagulation in miniature pigs induced the development of ischemic retinal territories associated with preretinal neovascularization. Preretinal partial pressure of oxygen (PO2) measurements on the ischemic territories, using O2-sensitive microelectrodes, established that the ischemic retinal areas were hypoxic. Scatter photocoagulation of these ischemic hypoxic territories restores the local PO2 to the normal values within 2 weeks. Hence, the reported inhibitory effect of photocoagulation on the development of retinal neovascularization could be due to a reversal effect on tissue hypoxia.

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Year:  1990        PMID： 2243683     DOI： 10.1016/s0161-6420(90)32414-4

Source DB:  PubMed          Journal:  Ophthalmology        ISSN： 0161-6420            Impact factor:   12.079


  15 in total

Review 1.  Ocular oxygen measurement.

Authors:  I M Hogeboom van Buggenum; G L van der Heijde; G J Tangelder; J W Reichert-Thoen
Journal:  Br J Ophthalmol       Date:  1996-06       Impact factor: 4.638

2.  A comparative study of the effects of argon and diode laser photocoagulation on retinal oxygenation.

Authors:  H Funatsu; C A Wilson; B A Berkowitz; P L Sonkin
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1997-03       Impact factor: 3.117

3.  Localisation of vascular endothelial growth factor and its receptors to cells of vascular and avascular epiretinal membranes.

Authors:  Y S Chen; S F Hackett; C L Schoenfeld; M A Vinores; S A Vinores; P A Campochiaro
Journal:  Br J Ophthalmol       Date:  1997-10       Impact factor: 4.638

4.  Decreased circulation in the feline choriocapillaris underlying retinal photocoagulation lesions.

Authors:  Christine J Lee; Jennifer H Smith; Jennifer J Kang-Mieler; Ewa Budzynski; Robert A Linsenmeier
Journal:  Invest Ophthalmol Vis Sci       Date:  2011-05-01       Impact factor: 4.799

5.  Dramatic inhibition of retinal and choroidal neovascularization by oral administration of a kinase inhibitor.

Authors:  M S Seo; N Kwak; H Ozaki; H Yamada; N Okamoto; E Yamada; D Fabbro; F Hofmann; J M Wood; P A Campochiaro
Journal:  Am J Pathol       Date:  1999-06       Impact factor: 4.307

Review 6.  Retinal oxygen: from animals to humans.

Authors:  Robert A Linsenmeier; Hao F Zhang
Journal:  Prog Retin Eye Res       Date:  2017-01-18       Impact factor: 21.198

Review 7.  Hypoxia and Dark Adaptation in Diabetic Retinopathy: Interactions, Consequences, and Therapy.

Authors:  David J Ramsey; G B Arden
Journal:  Curr Diab Rep       Date:  2015-12       Impact factor: 4.810

8.  Diabetic macular edema.

Authors:  Einar Stefánsson
Journal:  Saudi J Ophthalmol       Date:  2009-08-05

9.  Prolonged blockade of VEGF family members does not cause identifiable damage to retinal neurons or vessels.

Authors:  Shinji Ueno; Mary Ellen Pease; Delphine M Bonnet Wersinger; Tomohiro Masuda; Stanley A Vinores; Tamar Licht; Donald J Zack; Harry Quigley; Eli Keshet; Peter A Campochiaro
Journal:  J Cell Physiol       Date:  2008-10       Impact factor: 6.384

Review 10.  Physiology of vitreous surgery.

Authors:  Einar Stefánsson
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2008-11-26       Impact factor: 3.117
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