OBJECTIVE: To determine if differences in the GH-IGF-I axis exist between children of high and low aerobic fitness who are obese or of normal weight. DESIGN: 124 children (ages 8-11) divided into four groups based on BMI and VO₂max (mL O₂/kg fat free mass(FFM)/min): normal weight--high-fit (NH), normal weight--low-fit (NL), obese--high-fit (OH), and obese--low-fit (OL). Height, weight, skinfolds, body mass index (BMI), body fat percentage and predicted VO₂max (both ml/kg/min and ml/kg(FFM)/min) were assessed. Resting growth hormone (GH), total insulin-like growth factor 1 (total IGF-I), free insulin-like growth factor 1(free IGF-I), and insulin were measured using morning fasting blood samples. RESULTS: GH was greater in the NH group compared to the OL group only (p<0.01). No group differences existed for either total IGF-I (p=0.53) or free IGF-I (p=0.189). Insulin was greater in the OH and OL groups than the NH and NL groups (p<0.01). With groups combined (or overall), insulin and free IGF-I were related to fitness (insulin--ml/kg/min: r=-0.226, p<0.05 and ml/kg(FFM)/min: r=-0.212, p<0.05; free IGF-I--ml/kg/min: r=-0.219, p<0.01 and ml/kg(FFM)/min: r=-0.272, p<0.05). CONCLUSIONS: Fitness may contribute to the obesity related reduction of GH that may be involved with weight gain.
OBJECTIVE: To determine if differences in the GH-IGF-I axis exist between children of high and low aerobic fitness who are obese or of normal weight. DESIGN: 124 children (ages 8-11) divided into four groups based on BMI and VO₂max (mL O₂/kg fat free mass(FFM)/min): normal weight--high-fit (NH), normal weight--low-fit (NL), obese--high-fit (OH), and obese--low-fit (OL). Height, weight, skinfolds, body mass index (BMI), body fat percentage and predicted VO₂max (both ml/kg/min and ml/kg(FFM)/min) were assessed. Resting growth hormone (GH), total insulin-like growth factor 1 (total IGF-I), free insulin-like growth factor 1(free IGF-I), and insulin were measured using morning fasting blood samples. RESULTS:GH was greater in the NH group compared to the OL group only (p<0.01). No group differences existed for either total IGF-I (p=0.53) or free IGF-I (p=0.189). Insulin was greater in the OH and OL groups than the NH and NL groups (p<0.01). With groups combined (or overall), insulin and free IGF-I were related to fitness (insulin--ml/kg/min: r=-0.226, p<0.05 and ml/kg(FFM)/min: r=-0.212, p<0.05; free IGF-I--ml/kg/min: r=-0.219, p<0.01 and ml/kg(FFM)/min: r=-0.272, p<0.05). CONCLUSIONS: Fitness may contribute to the obesity related reduction of GH that may be involved with weight gain.
Authors: Lana M Bell; Katie Watts; Aris Siafarikas; Alisha Thompson; Nirubasini Ratnam; Max Bulsara; Judith Finn; Gerry O'Driscoll; Daniel J Green; Timothy W Jones; Elizabeth A Davis Journal: J Clin Endocrinol Metab Date: 2007-08-14 Impact factor: 5.958
Authors: Peter Hosick; Robert McMurray; A C Hackney; Claudio Battaglini; Terry Combs; Joanne Harrell Journal: Pediatr Exerc Sci Date: 2013-03-15 Impact factor: 2.333
Authors: Sitti Wahyuni; Marloes M A R van Dorst; Aldian I Amaruddin; Munawir Muhammad; Maria Yazdanbakhsh; Firdaus Hamid; Jan Pieter R Koopman; Erliyani Sartono Journal: Trop Med Int Health Date: 2020-12-02 Impact factor: 2.622