BACKGROUND: The incidence of therapy-related acute leukaemia (TRAL) in mitoxantrone treatment in multiple sclerosis (MS) is controversially discussed. METHODS AND RESULTS: In a retrospective meta-analysis from six centres, we observed six cases of acute myeloid leukaemia (AML) (incidence 0.41% for patients with mean follow up after end of treatment of 3.6 years, n = 1.156; incidence 0.25% for all patients, n = 2.261). Potential influencing factors such as myelotoxic or glucocorticosteroid pretreatment/cotreatment were present in all but one case of TRAL. Between 1990 and 2010, 11 cases of TRAL were reported to the Drug Commission of the German Medical Association (estimated risk of 0.09-0.13%). CONCLUSIONS: Regional differences in reported TRAL incidence may point to confounding cofactors such as administration protocols and cotreatments.
BACKGROUND: The incidence of therapy-related acute leukaemia (TRAL) in mitoxantrone treatment in multiple sclerosis (MS) is controversially discussed. METHODS AND RESULTS: In a retrospective meta-analysis from six centres, we observed six cases of acute myeloid leukaemia (AML) (incidence 0.41% for patients with mean follow up after end of treatment of 3.6 years, n = 1.156; incidence 0.25% for all patients, n = 2.261). Potential influencing factors such as myelotoxic or glucocorticosteroid pretreatment/cotreatment were present in all but one case of TRAL. Between 1990 and 2010, 11 cases of TRAL were reported to the Drug Commission of the German Medical Association (estimated risk of 0.09-0.13%). CONCLUSIONS: Regional differences in reported TRAL incidence may point to confounding cofactors such as administration protocols and cotreatments.
Authors: S Cotte; N von Ahsen; N Kruse; B Huber; A Winkelmann; U K Zettl; M Starck; N König; N Tellez; J Dörr; F Paul; F Zipp; F Lühder; H Koepsell; H Pannek; X Montalban; R Gold; A Chan Journal: Brain Date: 2009-07-15 Impact factor: 13.501
Authors: Peter Flachenecker; Kristin Stuke; Wolfgang Elias; Matthias Freidel; Judith Haas; Dorothea Pitschnau-Michel; Sebastian Schimrigk; Uwe K Zettl; Peter Rieckmann Journal: Dtsch Arztebl Int Date: 2008-02-15 Impact factor: 5.594
Authors: Ana M Pascual; Neus Téllez; Isabel Boscá; Javier Mallada; Antonio Belenguer; Inmaculada Abellán; Angel P Sempere; Pascual Fernández; Ma José Magraner; Francisco Coret; Miguel A Sanz; Xavier Montalbán; Bonaventura Casanova Journal: Mult Scler Date: 2009-10-13 Impact factor: 6.312
Authors: R G Ghalie; E Mauch; G Edan; H P Hartung; R E Gonsette; S Eisenmann; E Le Page; M D Butine; D E De Goodkin Journal: Mult Scler Date: 2002-10 Impact factor: 6.312
Authors: Hans-Peter Hartung; Richard Gonsette; Nikolaus König; Hubert Kwiecinski; Andreas Guseo; Sean P Morrissey; Hilmar Krapf; Thomas Zwingers Journal: Lancet Date: 2002 Dec 21-28 Impact factor: 79.321
Authors: Anja Mähler; Silvia Mandel; Mario Lorenz; Urs Ruegg; Erich E Wanker; Michael Boschmann; Friedemann Paul Journal: EPMA J Date: 2013-02-18 Impact factor: 6.543