| Literature DB >> 22434109 |
Joel Mainland1, Hiroaki Matsunami.
Abstract
Mammalian odorant receptors (ORs) are typically retained in the endoplasmic reticulum (ER) when expressed in heterologous cells. The RTP (Receptor-Transporting Protein) and REEP (Receptor Expression Enhancing Protein) family of proteins were first identified as partners for ORs, promoting cell-surface expression and leading to functional responses in heterologous cell systems. Like RAMPs, the RTP and REEP proteins appear to partner with GPCRs to promote cell-surface expression. Unlike RAMPs, they do not appear to alter the pharmacology of the partner receptor.Entities:
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Year: 2012 PMID： 22434109 DOI： 10.1007/978-1-4614-2364-5_7
Source DB: PubMed Journal: Adv Exp Med Biol ISSN： 0065-2598 Impact factor: 2.622