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Literature DB >> 22433839

Mechanisms regulating epidermal stem cells.

Abstract

The skin epidermis contains different appendages such as the hair follicle and the sebaceous glands. Recent studies demonstrated that several types of stem cells (SCs) exist in different niches within the epidermis and maintain discrete epidermal compartments, but the exact contribution of each SC populations under physiological conditions is still unclear. In addition, the precise mechanisms controlling the balance between proliferation and differentiation of epidermal SC still remain elusive. Recent studies provide new insights into these important questions by showing the contribution of hair follicle SC to the sebaceous lineage and the importance of chromatin modifications and micro-RNAs (miRs) in regulating epidermal SCs renewal and differentiation. In this review, we will discuss the importance of these papers to our understanding of the mechanisms that control epidermal SC functions.

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Year: 2012 PMID： 22433839 PMCID： PMC3343465 DOI： 10.1038/emboj.2012.67

Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 11.598

78 in total

1. Lgr5 marks cycling, yet long-lived, hair follicle stem cells.

Authors: Viljar Jaks; Nick Barker; Maria Kasper; Johan H van Es; Hugo J Snippert; Hans Clevers; Rune Toftgård
Journal: Nat Genet Date: 2008-10-12 Impact factor: 38.330

Review 2. Mechanisms of polycomb gene silencing: knowns and unknowns.

Authors: Jeffrey A Simon; Robert E Kingston
Journal: Nat Rev Mol Cell Biol Date: 2009-09-09 Impact factor: 94.444

3. Distinct self-renewal and differentiation phases in the niche of infrequently dividing hair follicle stem cells.

Authors: Ying V Zhang; Janice Cheong; Nichita Ciapurin; David J McDermitt; Tudorita Tumbar
Journal: Cell Stem Cell Date: 2009-08-06 Impact factor: 24.633

4. Rescue of key features of the p63-null epithelial phenotype by inactivation of Ink4a and Arf.

Authors: Xiaohua Su; Min Soon Cho; Young-Jin Gi; Bernard A Ayanga; Charles J Sherr; Elsa R Flores
Journal: EMBO J Date: 2009-06-04 Impact factor: 11.598

5. Monomethylation of histone H4-lysine 20 is involved in chromosome structure and stability and is essential for mouse development.

Authors: Hisanobu Oda; Ikuhiro Okamoto; Niall Murphy; Jianhua Chu; Sandy M Price; Michael M Shen; Maria Elena Torres-Padilla; Edith Heard; Danny Reinberg
Journal: Mol Cell Biol Date: 2009-02-17 Impact factor: 4.272

6. Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells.

Authors: Jamy C Peng; Anton Valouev; Tomek Swigut; Junmei Zhang; Yingming Zhao; Arend Sidow; Joanna Wysocka
Journal: Cell Date: 2009-12-24 Impact factor: 41.582

7. Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells.

Authors: Elena Ezhkova; H Amalia Pasolli; Joel S Parker; Nicole Stokes; I-hsin Su; Gregory Hannon; Alexander Tarakhovsky; Elaine Fuchs
Journal: Cell Date: 2009-03-20 Impact factor: 41.582

8. Lrig1 expression defines a distinct multipotent stem cell population in mammalian epidermis.

Authors: Kim B Jensen; Charlotte A Collins; Elisabete Nascimento; David W Tan; Michaela Frye; Satoshi Itami; Fiona M Watt
Journal: Cell Stem Cell Date: 2009-05-08 Impact factor: 24.633

9. Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells.

Authors: Xiaohua Shen; Woojin Kim; Yuko Fujiwara; Matthew D Simon; Yingchun Liu; Matthew R Mysliwiec; Guo-Cheng Yuan; Youngsook Lee; Stuart H Orkin
Journal: Cell Date: 2009-12-24 Impact factor: 41.582

10. DNMT1 maintains progenitor function in self-renewing somatic tissue.

Authors: George L Sen; Jason A Reuter; Daniel E Webster; Lilly Zhu; Paul A Khavari
Journal: Nature Date: 2010-01-17 Impact factor: 49.962

27 in total

1. Defining an epidermal stem cell epigenetic network.

Authors: Salvador Aznar Benitah
Journal: Nat Cell Biol Date: 2012-06-29 Impact factor: 28.824

2. Bridges between Cell Cycle Regulation and Self-Renewal Maintenance.

Authors: Patrick Viatour
Journal: Genes Cancer Date: 2012-11

Review 3. Epidermal Differentiation in Barrier Maintenance and Wound Healing.

Authors: Tongyu Cao Wikramanayake; Olivera Stojadinovic; Marjana Tomic-Canic
Journal: Adv Wound Care (New Rochelle) Date: 2014-03-01 Impact factor: 4.730

4. LGN plays distinct roles in oral epithelial stratification, filiform papilla morphogenesis and hair follicle development.

Authors: Kevin M Byrd; Kendall J Lough; Jeet H Patel; Carlos Patiño Descovich; T Anthony Curtis; Scott E Williams
Journal: Development Date: 2016-06-17 Impact factor: 6.868

5. Immature truncated O-glycophenotype of cancer directly induces oncogenic features.

Authors: Prakash Radhakrishnan; Sally Dabelsteen; Frey Brus Madsen; Chiara Francavilla; Katharina L Kopp; Catharina Steentoft; Sergey Y Vakhrushev; Jesper V Olsen; Lars Hansen; Eric P Bennett; Anders Woetmann; Guangliang Yin; Longyun Chen; Haiyan Song; Mads Bak; Ryan A Hlady; Staci L Peters; Rene Opavsky; Christenze Thode; Klaus Qvortrup; Katrine T-B G Schjoldager; Henrik Clausen; Michael A Hollingsworth; Hans H Wandall
Journal: Proc Natl Acad Sci U S A Date: 2014-08-12 Impact factor: 11.205

10. Overexpression of epigen during embryonic development induces reversible, epidermal growth factor receptor-dependent sebaceous gland hyperplasia.

Authors: Maik Dahlhoff; Daniela Frances; Jennifer E Kloepper; Ralf Paus; Matthias Schäfer; Catherin Niemann; Marlon R Schneider
Journal: Mol Cell Biol Date: 2014-06-02 Impact factor: 4.272