Literature DB >> 22432777

Transmissive olefination route to putative "morinol I" lignans.

Lihua Yao1, Bhaskar Pitta, P C Ravikumar, Matthew Purzycki, Fraser F Fleming.   

Abstract

A series of morinol-type lignans were rapidly assembled using a Grignard-based transmissive olefination. In combination with palladium-catalyzed arylations, the strategy provides stereoselective access to (7Z,7'E), (7E,7'E), and (7E,7'Z) morinol diastereomers and the (7Z,8'E) and (7E,8'E) conjugated analogues. Critical for the E/Z stereoselectivity is a new, general method for converting alkenenitriles to alkenemethanols that circumvents the enal E/Z isomerization commonly encountered during conventional i-Bu(2)AlH reduction.

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Year:  2012        PMID： 22432777      PMCID： PMC3331789          DOI： 10.1021/jo3001723

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


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