OBJECTIVES: To assess visual acuity (VA) while the patient is walking and to evaluate oscillopsia severity in patients with bilateral vestibulopathy (BV) and in patients with unilateral vestibular loss (UVL). DESIGN: Prospective study with a group of patients with BV, a group of patients with UVL, and a control group of healthy subjects. SETTING: Tertiary academic center. PARTICIPANTS: Thirty seven patients with BV(age range, 29-80 years), 11 patients with UVL (age range, 48-75 years), and 57 healthy subjects (age range 20-77 years). INTERVENTION: Computation of the difference between the VA measured in static conditions and in dynamic conditions while walking on a treadmill at 2, 4, and 6 km/h. Oscillopsia severity was assessed with a questionnaire that we developed. MAIN OUTCOME MEASURES: Differences in VA at 2, 4, and 6 km/h and oscillopsia severity score. RESULTS: As a group, patients with BV showed a significant increase of the VA differences compared with healthy subjects (P < .001) and patients with UVL (P < .001) for all 3 walking velocities. Normality thresholds were defined as healthy subjects' 95% CI. Sensitivity of the test was 97% for discriminating patients with BV. Moderate to extreme oscillopsia severity was found in 81% of patients with BV and in 9% of patients with UVL. Differences in VA did not correlate with oscillopsia severity scores in patients with BV (P > .05 for all comparisons). CONCLUSIONS: We designed a highly sensitive, simple, cost-effective protocol to assess dynamic VA under physiologic conditions and a questionnaire to determine oscillopsia severity. Both tools could be used for the evaluation of new treatments for BV and patients with UVL.
OBJECTIVES: To assess visual acuity (VA) while the patient is walking and to evaluate oscillopsia severity in patients with bilateral vestibulopathy (BV) and in patients with unilateral vestibular loss (UVL). DESIGN: Prospective study with a group of patients with BV, a group of patients with UVL, and a control group of healthy subjects. SETTING: Tertiary academic center. PARTICIPANTS: Thirty seven patients with BV(age range, 29-80 years), 11 patients with UVL (age range, 48-75 years), and 57 healthy subjects (age range 20-77 years). INTERVENTION: Computation of the difference between the VA measured in static conditions and in dynamic conditions while walking on a treadmill at 2, 4, and 6 km/h. Oscillopsia severity was assessed with a questionnaire that we developed. MAIN OUTCOME MEASURES: Differences in VA at 2, 4, and 6 km/h and oscillopsia severity score. RESULTS: As a group, patients with BV showed a significant increase of the VA differences compared with healthy subjects (P < .001) and patients with UVL (P < .001) for all 3 walking velocities. Normality thresholds were defined as healthy subjects' 95% CI. Sensitivity of the test was 97% for discriminating patients with BV. Moderate to extreme oscillopsia severity was found in 81% of patients with BV and in 9% of patients with UVL. Differences in VA did not correlate with oscillopsia severity scores in patients with BV (P > .05 for all comparisons). CONCLUSIONS: We designed a highly sensitive, simple, cost-effective protocol to assess dynamic VA under physiologic conditions and a questionnaire to determine oscillopsia severity. Both tools could be used for the evaluation of new treatments for BV and patients with UVL.
Authors: Evi Verbecque; Niels De Belder; Tessa Marijnissen; Luc Vereeck; Paul Van de Heyning; Ann Hallemans Journal: Eur Arch Otorhinolaryngol Date: 2018-02-28 Impact factor: 2.503
Authors: Olivier Peetermans; Bieke Dobbels; Griet Mertens; Julie Moyaert; Raymond van de Berg; Olivier Vanderveken; Paul Van de Heyning; Angélica Pérez Fornos; Nils Guinand; Marc J W Lammers; Vincent Van Rompaey Journal: Eur Arch Otorhinolaryngol Date: 2022-05-10 Impact factor: 2.503
Authors: Nils Guinand; Raymond Van de Berg; Samuel Cavuscens; Robert Stokroos; Maurizio Ranieri; Marco Pelizzone; Herman Kingma; Jean-Philippe Guyot; Angélica Pérez Fornos Journal: Front Neurosci Date: 2016-12-22 Impact factor: 4.677
Authors: Angelica Perez Fornos; Nils Guinand; Raymond van de Berg; Robert Stokroos; Silvestro Micera; Herman Kingma; Marco Pelizzone; Jean-Philippe Guyot Journal: Front Neurol Date: 2014-04-29 Impact factor: 4.003