Literature DB >> 22431173

Cytoplasmic vacuolization during exposure to drugs and other substances.

Toshihiko Aki1, Akina Nara, Koichi Uemura.   

Abstract

Cytoplasmic vacuolization upon exposure to a variety of chemicals and bioactive substances has been extensively reported. Nearly 30 years have passed since the description by Nobel Laureate Christian de Duve of the mechanism underlying the lysosomal accumulation of lipophilic weak bases referred to these substances as lysosomotropic agents. It has now been revealed, however, that vacuolization occurs upon exposure to compounds other than lipophilic weak bases. Vacuolization of organelles/vesicles other than acidic compartments has also now been reported. In this mini-review, we provide an overview of the origin, mechanism, and possible outcomes of cellular vacuolization during exposure to substances with lysosomotropic as well as other properties.

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Year:  2012        PMID： 22431173     DOI： 10.1007/s10565-012-9212-3

Source DB:  PubMed          Journal:  Cell Biol Toxicol        ISSN： 0742-2091            Impact factor:   6.691


  24 in total

1.  Vacuole-inducing compounds that disrupt endolysosomal trafficking stimulate production of exosomes by glioblastoma cells.

Authors:  Zehui Li; Nneka E Mbah; William A Maltese
Journal:  Mol Cell Biochem       Date:  2017-08-02       Impact factor: 3.396

Review 2.  Alcohol abuse and disorder of granulopoiesis.

Authors:  Xin Shi; Angelo L DeLucia; Jianxin Bao; Ping Zhang
Journal:  Pharmacol Ther       Date:  2019-03-01       Impact factor: 12.310

Review 3.  Methuosis: nonapoptotic cell death associated with vacuolization of macropinosome and endosome compartments.

Authors:  William A Maltese; Jean H Overmeyer
Journal:  Am J Pathol       Date:  2014-04-13       Impact factor: 4.307

4.  Disruption of endolysosomal trafficking pathways in glioma cells by methuosis-inducing indole-based chalcones.

Authors:  Nneka E Mbah; Jean H Overmeyer; William A Maltese
Journal:  Cell Biol Toxicol       Date:  2016-11-07       Impact factor: 6.691

5.  Side Effects of Neem Oil on the Midgut Endocrine Cells of the Green Lacewing Ceraeochrysa claveri (Navás) (Neuroptera: Chrysopidae).

Authors:  E L Scudeler; D C Santos
Journal:  Neotrop Entomol       Date:  2014-01-21       Impact factor: 1.434

6.  Lysosomal sequestration (trapping) of lipophilic amine (cationic amphiphilic) drugs in immortalized human hepatocytes (Fa2N-4 cells).

Authors:  Faraz Kazmi; Tiffini Hensley; Chad Pope; Ryan S Funk; Greg J Loewen; David B Buckley; Andrew Parkinson
Journal:  Drug Metab Dispos       Date:  2013-02-01       Impact factor: 3.922

7.  Fenretinide induces a new form of dynamin-dependent cell death in pediatric sarcoma.

Authors:  Eva Brack; Marco Wachtel; Anja Wolf; Andres Kaech; Urs Ziegler; Beat W Schäfer
Journal:  Cell Death Differ       Date:  2020-03-06       Impact factor: 15.828

8.  Involvement of PAR-4 in cannabinoid-dependent sensitization of osteosarcoma cells to TRAIL-induced apoptosis.

Authors:  Antonietta Notaro; Selenia Sabella; Ornella Pellerito; Riccardo Di Fiore; Anna De Blasio; Renza Vento; Giuseppe Calvaruso; Michela Giuliano
Journal:  Int J Biol Sci       Date:  2014-04-08       Impact factor: 6.580

9.  Amikacin-induced Fin Reduction is Mediated by Autophagy.

Authors:  I-Ting Tsai; Ying-Hsin Chen; Yau-Hung Chen; Yun-Hsin Wang
Journal:  J Toxicol Pathol       Date:  2013-04-22       Impact factor: 1.628

10.  Thymoquinone inhibits autophagy and induces cathepsin-mediated, caspase-independent cell death in glioblastoma cells.

Authors:  Ira O Racoma; Walter Hans Meisen; Qi-En Wang; Balveen Kaur; Altaf A Wani
Journal:  PLoS One       Date:  2013-09-09       Impact factor: 3.240
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