OBJECTIVE: Prospective cohort are inconsistent regarding the association between flavonols intake and the risk of coronary heart disease (CHD). The aim was to perform a meta-analysis to determine whether an association exists between them in observational studies. METHODS: We searched PUBMED and EMBASE databases for studies conducted from 1966 through January 2012. Data were independently abstracted by 2 investigators using a standardized protocol. Study-specific risk estimates were combined by using a random-effects model. RESULTS: A total of nine general population cohorts with 216,908 participants and more than 5249 CHD cases were included in the meta-analysis. The summary relative risk (RR) did not indicate a significant association between the highest flavonols intake and reduced risk of CHD (summary RR: 0.91; 95% CI: 0.83, 1.01). Furthermore, no significant association was found through the dose-response analysis (an increment of 20mg/day, summary RR: 0.96; 95% CI: 0.90, 1.03). CONCLUSIONS: Our results do not support a protective role of flavonols intake against CHD.
OBJECTIVE: Prospective cohort are inconsistent regarding the association between flavonols intake and the risk of coronary heart disease (CHD). The aim was to perform a meta-analysis to determine whether an association exists between them in observational studies. METHODS: We searched PUBMED and EMBASE databases for studies conducted from 1966 through January 2012. Data were independently abstracted by 2 investigators using a standardized protocol. Study-specific risk estimates were combined by using a random-effects model. RESULTS: A total of nine general population cohorts with 216,908 participants and more than 5249 CHD cases were included in the meta-analysis. The summary relative risk (RR) did not indicate a significant association between the highest flavonols intake and reduced risk of CHD (summary RR: 0.91; 95% CI: 0.83, 1.01). Furthermore, no significant association was found through the dose-response analysis (an increment of 20mg/day, summary RR: 0.96; 95% CI: 0.90, 1.03). CONCLUSIONS: Our results do not support a protective role of flavonols intake against CHD.
Authors: Chun Shing Kwok; S Matthijs Boekholdt; Marleen A H Lentjes; Yoon K Loke; Robert N Luben; Jessica K Yeong; Nicholas J Wareham; Phyo K Myint; Kay-Tee Khaw Journal: Heart Date: 2015-06-15 Impact factor: 5.994
Authors: Regina Menezes; Ana Rodriguez-Mateos; Antonia Kaltsatou; Antonio González-Sarrías; Arno Greyling; Christoforos Giannaki; Cristina Andres-Lacueva; Dragan Milenkovic; Eileen R Gibney; Julie Dumont; Manuel Schär; Mar Garcia-Aloy; Susana Alejandra Palma-Duran; Tatjana Ruskovska; Viktorija Maksimova; Emilie Combet; Paula Pinto Journal: Nutrients Date: 2017-02-09 Impact factor: 5.717
Authors: Jeffrey B Blumberg; Terri A Camesano; Aedin Cassidy; Penny Kris-Etherton; Amy Howell; Claudine Manach; Luisa M Ostertag; Helmut Sies; Ann Skulas-Ray; Joseph A Vita Journal: Adv Nutr Date: 2013-11-06 Impact factor: 8.701