| Literature DB >> 22429468 |
Qinghua Meng1, Baowei Zhao, Qiongfeng Xu, Xuesong Xu, Guanghui Deng, Chengyong Li, Linbo Luan, Feng Ren, Hailong Wang, Heng Xu, Yan Xu, Haibo Zhang, Jia-Ning Xiang, John D Elliott, Taylor B Guo, Yonggang Zhao, Wei Zhang, Hongtao Lu, Xichen Lin.
Abstract
Novel indole-propionic acid derivatives were developed as sphingosine-1-phosphate (S1P) receptor agonists through a systematic SAR study. The optimized and S1P(3) selective S1P(1) agonist 9f induced peripheral blood lymphocyte reduction in vivo and has an excellent efficacy in mouse experimental autoimmune encephalomyelitis (EAE).Entities:
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Year: 2012 PMID： 22429468 DOI： 10.1016/j.bmcl.2012.02.083
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823