L H Wang1, S X Zhou, R C Li, L R Zheng, J H Zhu, S J Hu, Y L Sun. 1. Department of Cardiovascular Sciences, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Abstract
OBJECTIVE: This study evaluated serum levels of the neuropeptides calcitonin gene-related peptide (CGRP) and substance P (SP) in coronary artery disease (CAD) patients with and without a history of diabetes mellitus (DM). METHODS: Patients undergoing coronary angiography for suspected myocardial ischaemia were divided into four groups depending on their clinical status: control group (no CAD or DM; n=44), DM group (DM without CAD; n=46), CAD group (stable CAD without DM; n=44) and DM+CAD group (stable CAD with DM; n=50). Serum levels of CGRP and SP were determined using radioimmunoassays. RESULTS: CGRP and SP levels in the DM and CAD groups were significantly lower than in the control group. The lowest levels of CGRP and SP were observed in the DM+CAD group. There were no significant differences in CGRP and SP levels between the DM group and the CAD group. CONCLUSION: CGRP and SP may have a role in the pathogenesis of CAD in patients with diabetes.
OBJECTIVE: This study evaluated serum levels of the neuropeptides calcitonin gene-related peptide (CGRP) and substance P (SP) in coronary artery disease (CAD) patients with and without a history of diabetes mellitus (DM). METHODS:Patients undergoing coronary angiography for suspected myocardial ischaemia were divided into four groups depending on their clinical status: control group (no CAD or DM; n=44), DM group (DM without CAD; n=46), CAD group (stable CAD without DM; n=44) and DM+CAD group (stable CAD with DM; n=50). Serum levels of CGRP and SP were determined using radioimmunoassays. RESULTS:CGRP and SP levels in the DM and CAD groups were significantly lower than in the control group. The lowest levels of CGRP and SP were observed in the DM+CAD group. There were no significant differences in CGRP and SP levels between the DM group and the CAD group. CONCLUSION:CGRP and SP may have a role in the pathogenesis of CAD in patients with diabetes.
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