Literature DB >> 22428159

Potent divalent inhibitors with rigid glucose click spacers for Pseudomonas aeruginosa lectin LecA.

Francesca Pertici1, Roland J Pieters.   

Abstract

The synthesis of a new rigid spacer based on carbohydrate-triazole repeating units and their incorporation into divalent systems is described. Inhibition studies showed that a well-matched system with a rigid spacer with flexible ends leads to the most potent inhibition of Pseudomonas aeruginosa lectin LecA.

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Year:  2012        PMID： 22428159     DOI： 10.1039/c2cc30234a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  13 in total

Review 1.  Multivalent glycoconjugates as anti-pathogenic agents.

Authors:  Anna Bernardi; Jesus Jiménez-Barbero; Alessandro Casnati; Cristina De Castro; Tamis Darbre; Franck Fieschi; Jukka Finne; Horst Funken; Karl-Erich Jaeger; Martina Lahmann; Thisbe K Lindhorst; Marco Marradi; Paul Messner; Antonio Molinaro; Paul V Murphy; Cristina Nativi; Stefan Oscarson; Soledad Penadés; Francesco Peri; Roland J Pieters; Olivier Renaudet; Jean-Louis Reymond; Barbara Richichi; Javier Rojo; Francesco Sansone; Christina Schäffer; W Bruce Turnbull; Trinidad Velasco-Torrijos; Sébastien Vidal; Stéphane Vincent; Tom Wennekes; Han Zuilhof; Anne Imberty
Journal:  Chem Soc Rev       Date:  2012-12-19       Impact factor: 54.564

Review 2.  Designing sugar mimetics: non-natural pyranosides as innovative chemical tools.

Authors:  Regis C Saliba; Nicola Lb Pohl
Journal:  Curr Opin Chem Biol       Date:  2016-09-10       Impact factor: 8.822

3.  Pseudomonas Aeruginosa Lectins As Targets for Novel Antibacterials.

Authors:  A V Grishin; M S Krivozubov; A S Karyagina; A L Gintsburg
Journal:  Acta Naturae       Date:  2015 Apr-Jun       Impact factor: 1.845

4.  Functionalization of a Rigid Divalent Ligand for LecA, a Bacterial Adhesion Lectin.

Authors:  Ou Fu; Aliaksei V Pukin; H C Quarles van Ufford; Johan Kemmink; Nico J de Mol; Roland J Pieters
Journal:  ChemistryOpen       Date:  2015-03-09       Impact factor: 2.911

5.  CuAAC click chemistry for the enhanced detection of novel alkyne-based natural product toxins.

Authors:  Edward S Hems; Ben A Wagstaff; Gerhard Saalbach; Robert A Field
Journal:  Chem Commun (Camb)       Date:  2018-10-12       Impact factor: 6.065

6.  The virulence factor LecB varies in clinical isolates: consequences for ligand binding and drug discovery.

Authors:  Roman Sommer; Stefanie Wagner; Annabelle Varrot; Corwin M Nycholat; Ariane Khaledi; Susanne Häussler; James C Paulson; Anne Imberty; Alexander Titz
Journal:  Chem Sci       Date:  2016-05-11       Impact factor: 9.825

7.  Efficient synthesis of phenylene-ethynylene rods and their use as rigid spacers in divalent inhibitors.

Authors:  Francesca Pertici; Norbert Varga; Arnoud van Duijn; Matias Rey-Carrizo; Anna Bernardi; Roland J Pieters
Journal:  Beilstein J Org Chem       Date:  2013-01-31       Impact factor: 2.883

8.  Expeditive synthesis of trithiotriazine-cored glycoclusters and inhibition of Pseudomonas aeruginosa biofilm formation.

Authors:  Meriem Smadhi; Sophie de Bentzmann; Anne Imberty; Marc Gingras; Raoudha Abderrahim; Peter G Goekjian
Journal:  Beilstein J Org Chem       Date:  2014-08-25       Impact factor: 2.883

9.  Assembly of Divalent Ligands and Their Effect on Divalent Binding to Pseudomonas aeruginosa Lectin LecA.

Authors:  Guangyun Yu; Anna Chiara Vicini; Roland J Pieters
Journal:  J Org Chem       Date:  2019-02-11       Impact factor: 4.354

10.  Synthesis and evaluation of porphyrin glycoconjugates varying in linker length: preliminary effects on the photodynamic inactivation of Mycobacterium smegmatis.

Authors:  Charlie F Dixon; Ana N Nottingham; Ana Frances Lozano; J Alexander Sizemore; Logan A Russell; Chelsea Valiton; Kimberly L Newell; Dominique Babin; William T Bridges; Matthew R Parris; David V Shchirov; Nicole L Snyder; Joshua V Ruppel
Journal:  RSC Adv       Date:  2021-02-10       Impact factor: 3.361
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