Literature DB >> 22427677

Preserved function of regulatory T cells in chronic HIV-1 infection despite decreased numbers in blood and tissue.

Mathieu Angin1, Douglas S Kwon, Hendrik Streeck, Fang Wen, Melanie King, Ashley Rezai, Kenneth Law, Tomoyuki C Hongo, Augustine Pyo, Alicja Piechocka-Trocha, Ildiko Toth, Florencia Pereyra, Musie Ghebremichael, Scott J Rodig, Danny A Milner, James M Richter, Marcus Altfeld, Daniel E Kaufmann, Bruce D Walker, Marylyn M Addo.   

Abstract

Regulatory T cells (Tregs) are potent immune modulators, but their role in human immunodeficiency virus type 1 (HIV-1) pathogenesis remains poorly understood. We performed a detailed analysis of the frequency and function of Tregs in a large cohort of HIV-1-infected individuals and HIV-1 negative controls. While HIV "elite controllers" and uninfected individuals had similar Treg numbers and frequencies, the absolute numbers of Tregs declined in blood and gut-associated lymphoid tissue in patients with chronic progressive HIV-1 infection. Despite quantitative changes in Tregs, HIV-1 infection was not associated with an impairment of ex vivo suppressive function of flow-sorted Tregs in both HIV controllers and untreated chronic progressors.

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Year:  2012        PMID： 22427677      PMCID： PMC3415814          DOI： 10.1093/infdis/jis236

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  16 in total

Review 1.  Regulatory T cells in HIV infection: pathogenic or protective participants in the immune response?

Authors:  Barbara Fazekas de St Groth; Alan L Landay
Journal:  AIDS       Date:  2008-03-30       Impact factor: 4.177

Review 2.  Regulatory T cells in the control of host-microorganism interactions (*).

Authors:  Yasmine Belkaid; Kristin Tarbell
Journal:  Annu Rev Immunol       Date:  2009       Impact factor: 28.527

3.  Comprehensive analysis of frequency and phenotype of T regulatory cells in HIV infection: CD39 expression of FoxP3+ T regulatory cells correlates with progressive disease.

Authors:  Julian Schulze Zur Wiesch; Adriana Thomssen; Philip Hartjen; Ilona Tóth; Clara Lehmann; Dirk Meyer-Olson; Kristina Colberg; Sebastian Frerk; Dalia Babikir; Stefan Schmiedel; Olaf Degen; Stefan Mauss; Jürgen Rockstroh; Schlomo Staszewski; Pavel Khaykin; Alexander Strasak; Ansgar W Lohse; Gerd Fätkenheuer; Joachim Hauber; Jan van Lunzen
Journal:  J Virol       Date:  2010-11-03       Impact factor: 5.103

Review 4.  Regulatory T-cell adoptive immunotherapy: potential for treatment of autoimmunity.

Authors:  Graham P Wright; Michael R Ehrenstein; Hans J Stauss
Journal:  Expert Rev Clin Immunol       Date:  2011-03       Impact factor: 4.473

5.  Regulatory T cells control HIV replication in activated T cells through a cAMP-dependent mechanism.

Authors:  Maria E Moreno-Fernandez; Cesar Mauricio Rueda; Laura K Rusie; Claire A Chougnet
Journal:  Blood       Date:  2011-03-23       Impact factor: 22.113

6.  Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease.

Authors:  David Favre; Jeff Mold; Peter W Hunt; Bittoo Kanwar; P'ng Loke; Lillian Seu; Jason D Barbour; Margaret M Lowe; Anura Jayawardene; Francesca Aweeka; Yong Huang; Daniel C Douek; Jason M Brenchley; Jeffrey N Martin; Frederick M Hecht; Steven G Deeks; Joseph M McCune
Journal:  Sci Transl Med       Date:  2010-05-19       Impact factor: 17.956

7.  Protective HIV-specific CD8+ T cells evade Treg cell suppression.

Authors:  Shokrollah Elahi; Warren L Dinges; Nicholas Lejarcegui; Kerry J Laing; Ann C Collier; David M Koelle; M Juliana McElrath; Helen Horton
Journal:  Nat Med       Date:  2011-07-17       Impact factor: 53.440

8.  HIV+ elite controllers have low HIV-specific T-cell activation yet maintain strong, polyfunctional T-cell responses.

Authors:  Rachel E Owen; John W Heitman; Dale F Hirschkorn; Marion C Lanteri; Hope H Biswas; Jeffrey N Martin; Melissa R Krone; Steven G Deeks; Philip J Norris
Journal:  AIDS       Date:  2010-05-15       Impact factor: 4.177

Review 9.  FOXP3+ regulatory T cells in the human immune system.

Authors:  Shimon Sakaguchi; Makoto Miyara; Cristina M Costantino; David A Hafler
Journal:  Nat Rev Immunol       Date:  2010-06-18       Impact factor: 53.106

10.  DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cells.

Authors:  Udo Baron; Stefan Floess; Georg Wieczorek; Katrin Baumann; Andreas Grützkau; Jun Dong; Andreas Thiel; Tina J Boeld; Petra Hoffmann; Matthias Edinger; Ivana Türbachova; Alf Hamann; Sven Olek; Jochen Huehn
Journal:  Eur J Immunol       Date:  2007-09       Impact factor: 5.532
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  36 in total

Review 1.  Homeostasis and function of regulatory T cells in HIV/SIV infection.

Authors:  Maria E Moreno-Fernandez; Pietro Presicce; Claire A Chougnet
Journal:  J Virol       Date:  2012-07-18       Impact factor: 5.103

Review 2.  Immune responses during spontaneous control of HIV and AIDS: what is the hope for a cure?

Authors:  A Saez-Cirion; B Jacquelin; F Barré-Sinoussi; M Müller-Trutwin
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2014-05-12       Impact factor: 6.237

3.  Defective pneumococcal-specific Th1 responses in HIV-infected adults precedes a loss of control of pneumococcal colonization.

Authors:  Sarah J Glennie; Dominic Banda; Kate Gould; Jason Hinds; Arox Kamngona; Dean D B Everett; Neil A Williams; Robert S Heyderman
Journal:  Clin Infect Dis       Date:  2012-09-28       Impact factor: 9.079

4.  Identification of HIV-1-specific regulatory T-cells using HLA class II tetramers.

Authors:  Mathieu Angin; Melanie King; Marcus Altfeld; Bruce D Walker; Kai W Wucherpfennig; Marylyn M Addo
Journal:  AIDS       Date:  2012-10-23       Impact factor: 4.177

5.  New tools to expand regulatory T cells from HIV-1-infected individuals.

Authors:  Mathieu Angin; Melanie King; Marylyn Martina Addo
Journal:  J Vis Exp       Date:  2013-05-30       Impact factor: 1.355

6.  Forkhead box protein 3(+) regulatory T cells and Helios(+) subset in perinatally acquired HIV.

Authors:  G Degaffe; R Zakhour; W Zhang; G A Contreras; C S Bell; G Rodriguez; G Del Bianco; N Pérez; L J Benjamins; J R Murphy; G P Heresi; D Q Tran
Journal:  Clin Exp Immunol       Date:  2015-04       Impact factor: 4.330

7.  Phenotypic characterization of regulatory T cells from antiretroviral-naive HIV-1-infected people.

Authors:  Georgia N Ambada; Claudine E Ntsama; Nadesh N Nji; Loveline N Ngu; Carole N Sake; Abel Lissom; Flaurent T Tchouangeu; Jules Tchadji; Martin Sosso; François-Xavier Etoa; Godwin W Nchinda
Journal:  Immunology       Date:  2017-05-18       Impact factor: 7.397

8.  Reciprocal relationship of T regulatory cells and monocytic myeloid-derived suppressor cells in LP-BM5 murine retrovirus-induced immunodeficiency.

Authors:  Megan A O'Connor; Jennifer L Vella; William R Green
Journal:  J Gen Virol       Date:  2015-08-06       Impact factor: 3.891

Review 9.  Sex-based differences in HIV type 1 pathogenesis.

Authors:  Marylyn M Addo; Marcus Altfeld
Journal:  J Infect Dis       Date:  2014-07-15       Impact factor: 5.226

Review 10.  CD4(+) T-cell depletion in HIV infection: mechanisms of immunological failure.

Authors:  Afam A Okoye; Louis J Picker
Journal:  Immunol Rev       Date:  2013-07       Impact factor: 12.988
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