Literature DB >> 22426491

Detecting overlapping protein complexes in protein-protein interaction networks.

Tamás Nepusz1, Haiyuan Yu, Alberto Paccanaro.   

Abstract

We introduce clustering with overlapping neighborhood expansion (ClusterONE), a method for detecting potentially overlapping protein complexes from protein-protein interaction data. ClusterONE-derived complexes for several yeast data sets showed better correspondence with reference complexes in the Munich Information Center for Protein Sequence (MIPS) catalog and complexes derived from the Saccharomyces Genome Database (SGD) than the results of seven popular methods. The results also showed a high extent of functional homogeneity.

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Year:  2012        PMID： 22426491      PMCID： PMC3543700          DOI： 10.1038/nmeth.1938

Source DB:  PubMed          Journal:  Nat Methods        ISSN： 1548-7091            Impact factor:   28.547


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