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Literature DB >> 22426190

Ubiquitin ligases: Taming the APC.

Ian T Foe, David P Toczyski.

Abstract

Entities: Disease

Mesh：

Substances：

Year: 2012 PMID： 22426190 DOI： 10.1038/nchembio.923

Source DB: PubMed Journal: Nat Chem Biol ISSN： 1552-4450 Impact factor: 15.040

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10 in total

1. Ubiquitination of Cdc20 by the APC occurs through an intramolecular mechanism.

Authors: Ian T Foe; Scott A Foster; Stephanie K Cheung; Steven Z DeLuca; David O Morgan; David P Toczyski
Journal: Curr Biol Date: 2011-11-10 Impact factor: 10.834

2. The WD40 propeller domain of Cdh1 functions as a destruction box receptor for APC/C substrates.

Authors: Claudine Kraft; Hartmut C Vodermaier; Sebastian Maurer-Stroh; Frank Eisenhaber; Jan-Michael Peters
Journal: Mol Cell Date: 2005-05-27 Impact factor: 17.970

3. Crystal structure of the APC10/DOC1 subunit of the human anaphase-promoting complex.

Authors: K S Wendt; H C Vodermaier; U Jacob; C Gieffers; M Gmachl; J M Peters; R Huber; P Sondermann
Journal: Nat Struct Biol Date: 2001-09

4. Homeostatic control of mitotic arrest.

Authors: Gianluca Varetti; Claudia Guida; Stefano Santaguida; Elena Chiroli; Andrea Musacchio
Journal: Mol Cell Date: 2011-12-09 Impact factor: 17.970

5. Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage.

Authors: Xing Zeng; Frederic Sigoillot; Shantanu Gaur; Sungwoon Choi; Kathleen L Pfaff; Dong-Chan Oh; Nathaniel Hathaway; Nevena Dimova; Gregory D Cuny; Randall W King
Journal: Cancer Cell Date: 2010-10-19 Impact factor: 31.743

Ubiquitin ligases: Taming the APC.

1. Ubiquitination of Cdc20 by the APC occurs through an intramolecular mechanism.

2. The WD40 propeller domain of Cdh1 functions as a destruction box receptor for APC/C substrates.

3. Crystal structure of the APC10/DOC1 subunit of the human anaphase-promoting complex.

4. Homeostatic control of mitotic arrest.

5. Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage.

6. The APC subunit Doc1 promotes recognition of the substrate destruction box.

7. Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation.

8. TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1.

9. Structures of APC/C(Cdh1) with substrates identify Cdh1 and Apc10 as the D-box co-receptor.

10. An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination.