Literature DB >> 22425567

Unambiguous structure of atractyloside and carboxyatractyloside.

Jean-Frédéric Sanchez1, Brice Kauffmann, Axelle Grélard, Corinne Sanchez, Véronique Trézéguet, Ivan Huc, Guy J-M Lauquin.   

Abstract

Atractyloside (ATR) was characterized in 1868 and until now structural studies on diterpenic moiety had been done through the characterization of ATR derivatives; while the glycosidic moiety seemed to be a β-D-glucopyranose a recent crystal structure of the mitochondrial ATP/ADP carrier in complex with CATR showed an α-D-glucopyranose. We decided to re-examine the ATR and CATR structures by crystallographic study of ATR.
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID: 22425567     DOI: 10.1016/j.bmcl.2012.02.040

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  3 in total

1.  Mitochondrial Energy-Regulating Effect of Atractyloside Inhibits Hepatocellular Steatosis Through the Activation of Autophagy.

Authors:  Pengfei Zhang; Lijun Li; Huimin Sun; Yipeng Zhang; Guoliang Zhang; Tianyu Zhang; Changchun Zeng
Journal:  Front Pharmacol       Date:  2020-09-30       Impact factor: 5.810

2.  The transmembrane prolines of the mitochondrial ADP/ATP carrier are involved in nucleotide binding and transport and its biogenesis.

Authors:  Marion Babot; Corinne Blancard; Ludovic Pelosi; Guy J-M Lauquin; Véronique Trézéguet
Journal:  J Biol Chem       Date:  2012-02-09       Impact factor: 5.157

Review 3.  The mitochondrial ADP/ATP carrier exists and functions as a monomer.

Authors:  Edmund R S Kunji; Jonathan J Ruprecht
Journal:  Biochem Soc Trans       Date:  2020-08-28       Impact factor: 5.407

  3 in total

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