BACKGROUND: Elevated levels of total plasma homocysteine are a risk factor for atherosclerotic disease. AIMS: The rationale behind this study is to explore the correlation between degree and site of coronary lesion and hyperhomocysteinemia in Lebanese CAD patients and assess environmental and genetic factors for elevated levels of total plasma homocysteine. METHODS: A total of 2644 patients were analyzed for traditional CAD risk factors. Logistic regression was performed to determine the association of hyperhomocysteinemia with degree and site of coronary lesions controlling for risk factors. Environmental and genetic factors for hyperhomocysteinemia were analyzed by logistic regression using a candidate gene approach. RESULTS: Traditional risk factors were correlated with stenosis. Hyperhomocysteinemia associated with increased risk of overall stenosis, and risk of mild and severe occlusion in major arteries. Hyperhomocysteinemia and hypertension were highly correlated suggesting that hyperhomocysteinemia acts as a hypertensive agent leading to CAD. Diuretics and genetic polymorphisms in MTHFR and SLCO1B1 were associated with hyperhomocysteinemia. CONCLUSIONS: Hyperhomocysteinemia is a medical indicator of specific vessel stenosis in the Lebanese population. Hypertension is a major link between hyperhomocysteinemia and CAD occurrence. Genetic polymorphisms and diuretics' intake explain partly elevated homocysteine levels. This study has important implications in CAD risk prediction.
BACKGROUND: Elevated levels of total plasma homocysteine are a risk factor for atherosclerotic disease. AIMS: The rationale behind this study is to explore the correlation between degree and site of coronary lesion and hyperhomocysteinemia in Lebanese CAD patients and assess environmental and genetic factors for elevated levels of total plasma homocysteine. METHODS: A total of 2644 patients were analyzed for traditional CAD risk factors. Logistic regression was performed to determine the association of hyperhomocysteinemia with degree and site of coronary lesions controlling for risk factors. Environmental and genetic factors for hyperhomocysteinemia were analyzed by logistic regression using a candidate gene approach. RESULTS: Traditional risk factors were correlated with stenosis. Hyperhomocysteinemia associated with increased risk of overall stenosis, and risk of mild and severe occlusion in major arteries. Hyperhomocysteinemia and hypertension were highly correlated suggesting that hyperhomocysteinemia acts as a hypertensive agent leading to CAD. Diuretics and genetic polymorphisms in MTHFR and SLCO1B1 were associated with hyperhomocysteinemia. CONCLUSIONS:Hyperhomocysteinemia is a medical indicator of specific vessel stenosis in the Lebanese population. Hypertension is a major link between hyperhomocysteinemia and CAD occurrence. Genetic polymorphisms and diuretics' intake explain partly elevated homocysteine levels. This study has important implications in CAD risk prediction.
Authors: Mahmoud Merhi; Sally Demirdjian; Essa Hariri; Nada Sabbah; Sonia Youhanna; Michella Ghassibe-Sabbagh; Joseph Naoum; Marc Haber; Raed Othman; Samer Kibbani; Elie Chammas; Roy Kanbar; Hamid El Bayeh; Youssef Chami; Antoine Abchee; Daniel E Platt; Pierre Zalloua; Georges Khazen Journal: Inflamm Res Date: 2015-04-24 Impact factor: 4.575
Authors: Aline Milane; Georges Khazen; Nabil Zeineddine; Mazen Amro; Leila Masri; Michella Ghassibe-Sabbagh; Sonia Youhanna; Angelique K Salloum; Marc Haber; Daniel E Platt; Jean-Baptiste Cazier; Raed Othman; Samer Kabbani; Hana Sbeite; Youssef Chami; Elie Chammas; Hamid El Bayeh; Dominique Gauguier; Antoine B Abchee; Pierre Zalloua; Antoine Barbari Journal: Int J Clin Exp Med Date: 2015-09-15
Authors: Daniel E Platt; Essa Hariri; Pascale Salameh; Mahmoud Merhi; Nada Sabbah; Mariana Helou; Francis Mouzaya; Rita Nemer; Yasser Al-Sarraj; Hatem El-Shanti; Antoine B Abchee; Pierre A Zalloua Journal: Diabetol Metab Syndr Date: 2017-03-21 Impact factor: 3.320