OBJECTIVE: Symptomatic predictors of influenza could assess risks and improve decisions about isolation and outpatient treatment. To develop such predictors, we undertook a prospective analysis of pandemic (H1N1) 2009 and seasonal influenza (H3N2) in patients attending fever clinics. METHODS: From 1 May 2009 to 1 January 2010, all adult patients admitted to fever clinics for suspected influenza, confirmed by real time RT-PCR, were enrolled. Predictors of influenza virus infection were selected with logistic regression models. Measures of sensitivity, specificity, positive and negative likelihood ratios (LRs) were calculated to identify the best predictors. RESULTS: The clinical features and routine blood test results of influenza (H1N1) 2009 and seasonal influenza were similar. The positive and negative LRs of current US CDC influenza-like illness (ILI) criteria were modest in predicting influenza infection. Our modified clinic predictors improved the ability of the positive and negative LRs to recognize pandemic (H1N1) 2009 and seasonal influenza. The revised criteria are: fever >38 °C accompanied by at least one of the following-cough, arthralgia or relative lymphopenia. CONCLUSION: Patients with symptoms and signs that meet the new criteria are likely to have influenza and timely antiviral therapy may be appropriate. In addition, physicians should ascertain if influenza is circulating within the community or if there is a contact history of influenza and combine this information with the newly developed criteria to clinically diagnose influenza. Copyright Â
OBJECTIVE: Symptomatic predictors of influenza could assess risks and improve decisions about isolation and outpatient treatment. To develop such predictors, we undertook a prospective analysis of pandemic (H1N1) 2009 and seasonal influenza (H3N2) in patients attending fever clinics. METHODS: From 1 May 2009 to 1 January 2010, all adult patients admitted to fever clinics for suspected influenza, confirmed by real time RT-PCR, were enrolled. Predictors of influenza virus infection were selected with logistic regression models. Measures of sensitivity, specificity, positive and negative likelihood ratios (LRs) were calculated to identify the best predictors. RESULTS: The clinical features and routine blood test results of influenza (H1N1) 2009 and seasonal influenza were similar. The positive and negative LRs of current US CDC influenza-like illness (ILI) criteria were modest in predicting influenza infection. Our modified clinic predictors improved the ability of the positive and negative LRs to recognize pandemic (H1N1) 2009 and seasonal influenza. The revised criteria are: fever >38 °C accompanied by at least one of the following-cough, arthralgia or relative lymphopenia. CONCLUSION:Patients with symptoms and signs that meet the new criteria are likely to have influenza and timely antiviral therapy may be appropriate. In addition, physicians should ascertain if influenza is circulating within the community or if there is a contact history of influenza and combine this information with the newly developed criteria to clinically diagnose influenza. Copyright Â
Authors: Woo Joo Kim; Jin Soo Lee; Chang Kyu Lee; Hee Jin Cheong; Mijeong Kim; Javier Sawchik Monegal; Rute Carneiro; Moe H Kyaw; François Haguinet; Riju Ray; Gonçalo Matias Journal: J Korean Med Sci Date: 2017-03 Impact factor: 2.153
Authors: D G Hoy; T Raikoti; E Smith; A Tuzakana; T Gill; K Matikarai; J Tako; A Jorari; F Blyth; A Pitaboe; R Buchbinder; I Kalauma; P Brooks; C Lepers; A Woolf; A Briggs; L March Journal: BMC Musculoskelet Disord Date: 2018-08-16 Impact factor: 2.362
Authors: Seong-Heon Wie; Byung Hak So; Joon Young Song; Hee Jin Cheong; Yu Bin Seo; Sung Hyuk Choi; Ji Yun Noh; Ji Hyeon Baek; Jin Soo Lee; Hyo Youl Kim; Young Keun Kim; Won Suk Choi; Jacob Lee; Hye Won Jeong; Woo Joo Kim Journal: PLoS One Date: 2013-05-03 Impact factor: 3.240