BACKGROUND: Smoking and hypertension increase the risk of aneurismal subarachnoid haemorrhage (SAH) two to threefold whereas a familial predisposition increases the risk sixfold. We assessed the additional risk of smoking and hypertension for the presence of an intracranial aneurysm (IA) in first-degree relatives of patients with familial SAH. METHODS: We studied first-degree relatives of patients with familial SAH who were screened for the presence of aneurysms. RRs with corresponding 95% CIs for the risk of IA were calculated for smoking and hypertension. RESULTS: The RRs were 1.5 (95% CI 0.7 to 3.2) for smoking, 1.9 (95% CI 1.0 to 3.7) for hypertension and 2.7 (95% CI 1.4 to 5.3) for smoking plus hypertension. The increased RR for hypertension was found in both women and men, but the increased RR for smoking was found in women only. CONCLUSION: The extent of the increased risk of smoking and hypertension for the presence of IA in first-degree relatives of patients with familial SAH is similar to that in patients without familial predisposition. Risk factor profiles should be included in future genetic studies.
BACKGROUND: Smoking and hypertension increase the risk of aneurismal subarachnoid haemorrhage (SAH) two to threefold whereas a familial predisposition increases the risk sixfold. We assessed the additional risk of smoking and hypertension for the presence of an intracranial aneurysm (IA) in first-degree relatives of patients with familial SAH. METHODS: We studied first-degree relatives of patients with familial SAH who were screened for the presence of aneurysms. RRs with corresponding 95% CIs for the risk of IA were calculated for smoking and hypertension. RESULTS: The RRs were 1.5 (95% CI 0.7 to 3.2) for smoking, 1.9 (95% CI 1.0 to 3.7) for hypertension and 2.7 (95% CI 1.4 to 5.3) for smoking plus hypertension. The increased RR for hypertension was found in both women and men, but the increased RR for smoking was found in women only. CONCLUSION: The extent of the increased risk of smoking and hypertension for the presence of IA in first-degree relatives of patients with familial SAH is similar to that in patients without familial predisposition. Risk factor profiles should be included in future genetic studies.
Authors: S Bacigaluppi; M Piccinelli; L Antiga; A Veneziani; T Passerini; P Rampini; M Zavanone; P Severi; G Tredici; G Zona; T Krings; E Boccardi; S Penco; M Fontanella Journal: Neurosurg Rev Date: 2013-12-04 Impact factor: 3.042
Authors: Charlotte C M Zuurbier; Romain Bourcier; Pacôme Constant Dit Beaufils; Richard Redon; Hubert Desal; Anne S E Bor; Antti E Lindgren; Gabriel J E Rinkel; Jacoba P Greving; Ynte M Ruigrok Journal: Stroke Date: 2022-02-11 Impact factor: 7.914
Authors: Liselore A Mensing; Gabriel J E Rinkel; Monique H M Vlak; Irene C van der Schaaf; Ynte M Ruigrok Journal: PLoS One Date: 2016-04-22 Impact factor: 3.240