Literature DB >> 22422851

HIV-1 proviral DNA loads (as determined by quantitative PCR) in patients subjected to structured treatment interruption after antiretroviral therapy failure.

Shirley V Komninakis1, Domingos E M Santos, Carlos Santos, Márcia P R Oliveros, Sabri Sanabani, Ricardo S Diaz.   

Abstract

The impact of Structured Treatment Interruption (STI) in peripheral blood mononuclear cell (PBMC) proviral reservoirs in 41 highly active antiretroviral therapy (HAART)-treated viremic individuals at baseline and 12 weeks after STI was determined using quantitative PCR (qPCR). Viral load increased 0.7 log(10) and CD4 decreased 97.5 cells/mm(3) after 12 weeks. A total of 28 of the 41 individuals showed an increased proviral load, 19 with a statistically significant increase above 10%. An increase in active viral replication is an important factor in the replenishment of the proviral reservoir even for short time periods.

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Year:  2012        PMID： 22422851      PMCID： PMC3372152          DOI： 10.1128/JCM.00393-12

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  10 in total

1.  PCR-Based assay to quantify human immunodeficiency virus type 1 DNA in peripheral blood mononuclear cells.

Authors:  C Christopherson; Y Kidane; B Conway; J Krowka; H Sheppard; S Kwok
Journal:  J Clin Microbiol       Date:  2000-02       Impact factor: 5.948

2.  Proviral HIV-DNA predicts viral rebound and viral setpoint after structured treatment interruptions.

Authors:  Sabine Yerly; Huldrych F Günthard; Catherine Fagard; Béda Joos; Thomas V Perneger; Bernard Hirschel; Luc Perrin
Journal:  AIDS       Date:  2004-09-24       Impact factor: 4.177

3.  HIV-infected individuals receiving effective antiviral therapy for extended periods of time continually replenish their viral reservoir.

Authors:  Tae-Wook Chun; David C Nickle; J Shawn Justement; Danielle Large; Alice Semerjian; Marcel E Curlin; M Angeline O'Shea; Claire W Hallahan; Marybeth Daucher; Douglas J Ward; Susan Moir; James I Mullins; Colin Kovacs; Anthony S Fauci
Journal:  J Clin Invest       Date:  2005-11       Impact factor: 14.808

4.  Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection.

Authors:  T W Chun; L Carruth; D Finzi; X Shen; J A DiGiuseppe; H Taylor; M Hermankova; K Chadwick; J Margolick; T C Quinn; Y H Kuo; R Brookmeyer; M A Zeiger; P Barditch-Crovo; R F Siliciano
Journal:  Nature       Date:  1997-05-08       Impact factor: 49.962

5.  Virological and immunological effects of treatment interruptions in HIV-1 infected patients with treatment failure.

Authors:  V Miller; C Sabin; K Hertogs; S Bloor; J Martinez-Picado; R D'Aquila; B Larder; T Lutz; P Gute; E Weidmann; H Rabenau; A Phillips; S Staszewski
Journal:  AIDS       Date:  2000-12-22       Impact factor: 4.177

6.  Relationship between the size of the human immunodeficiency virus type 1 (HIV-1) reservoir in peripheral blood CD4+ T cells and CD4+:CD8+ T cell ratios in aviremic HIV-1-infected individuals receiving long-term highly active antiretroviral therapy.

Authors:  Tae-Wook Chun; J Shawn Justement; Punita Pandya; Claire W Hallahan; Mary McLaughlin; Shuying Liu; Linda A Ehler; Colin Kovacs; Anthony S Fauci
Journal:  J Infect Dis       Date:  2002-05-08       Impact factor: 5.226

7.  Virologic and immunologic consequences of discontinuing combination antiretroviral-drug therapy in HIV-infected patients with detectable viremia.

Authors:  S G Deeks; T Wrin; T Liegler; R Hoh; M Hayden; J D Barbour; N S Hellmann; C J Petropoulos; J M McCune; M K Hellerstein; R M Grant
Journal:  N Engl J Med       Date:  2001-02-15       Impact factor: 91.245

8.  Quantification of human immunodeficiency virus type 1 proviral load by a TaqMan real-time PCR assay.

Authors:  N Désiré; A Dehée; V Schneider; C Jacomet; C Goujon; P M Girard; W Rozenbaum; J C Nicolas
Journal:  J Clin Microbiol       Date:  2001-04       Impact factor: 5.948

9.  HIV-1 can persist in aged memory CD4+ T lymphocytes with minimal signs of evolution after 8.3 years of effective highly active antiretroviral therapy.

Authors:  Hans S L M Nottet; Sabine J van Dijk; Ewout B Fanoy; Irma W Goedegebuure; Dorien de Jong; Nienke Vrisekoop; Debbie van Baarle; Valerie Boltz; Sarah Palmer; Jan C C Borleffs; Charles A B Boucher
Journal:  J Acquir Immune Defic Syndr       Date:  2009-04-01       Impact factor: 3.731

10.  Human immunodeficiency virus type 1 in the semen of men receiving highly active antiretroviral therapy.

Authors:  H Zhang; G Dornadula; M Beumont; L Livornese; B Van Uitert; K Henning; R J Pomerantz
Journal:  N Engl J Med       Date:  1998-12-17       Impact factor: 91.245
  10 in total
  8 in total

1.  In vivo HIV-1 hypermutation and viral loads among antiretroviral-naive Brazilian patients.

Authors:  Mariana Leão de Lima-Stein; Wagner Tadeu Alkmim; Maria Clara de Souza Bizinoto; Luis Fernandez Lopez; Marcelo Nascimento Burattini; Juliana Terzi Maricato; Leila Giron; Maria Cecília Araripe Sucupira; Ricardo Sobhie Diaz; Luiz Mario Janini
Journal:  AIDS Res Hum Retroviruses       Date:  2014-08-25       Impact factor: 2.205

2.  Pace of Coreceptor Tropism Switch in HIV-1-Infected Individuals after Recent Infection.

Authors:  Muhammad Shoaib Arif; James Hunter; Ana Rachel Léda; Jean Paulo Lopes Zukurov; Sadia Samer; Michelle Camargo; Juliana Galinskas; Esper Georges Kallás; Shirley Vasconcelos Komninakis; Luiz Mario Janini; Maria Cecilia Sucupira; Ricardo Sobhie Diaz
Journal:  J Virol       Date:  2017-09-12       Impact factor: 5.103

3.  Antiretroviral Drug-Resistance Mutations on the Gag Gene: Mutation Dynamics during Analytic Treatment Interruption among Individuals Experiencing Virologic Failure.

Authors:  James R Hunter; Domingos E Matos Dos Santos; Patricia Munerato; Luiz Mario Janini; Adauto Castelo; Maria Cecilia Sucupira; Hong-Ha M Truong; Ricardo Sobhie Diaz
Journal:  Pathogens       Date:  2022-05-03

Review 4.  Clinical Relevance of Total HIV DNA in Peripheral Blood Mononuclear Cell Compartments as a Biomarker of HIV-Associated Neurocognitive Disorders (HAND).

Authors:  Vurayai Ruhanya; Graeme B Jacobs; Richard H Glashoff; Susan Engelbrecht
Journal:  Viruses       Date:  2017-10-31       Impact factor: 5.048

5.  Laboratory surrogate markers of residual HIV replication among distinct groups of individuals under antiretroviral therapy.

Authors:  Leila Bertoni Giron; Simone B Tenore; Luis Mario Ramos Janini; Maria Cecilia Araripe Sucupira; Ricardo Sobhie Diaz
Journal:  PLoS One       Date:  2019-06-17       Impact factor: 3.240

6.  Immunogenicity of personalized dendritic-cell therapy in HIV-1 infected individuals under suppressive antiretroviral treatment: interim analysis from a phase II clinical trial.

Authors:  Marcella Vassão de Almeida Baptista; Laís Teodoro da Silva; Sadia Samer; Telma Miyuki Oshiro; Iart Luca Shytaj; Leila B Giron; Nathalia Mantovani Pena; Nicolly Cruz; Gisele Cristina Gosuen; Paulo Roberto Abrão Ferreira; Edécio Cunha-Neto; Juliana Galinskas; Danilo Dias; Maria Cecilia Araripe Sucupira; Cesar de Almeida-Neto; Reinaldo Salomão; Alberto José da Silva Duarte; Luís Mário Janini; James R Hunter; Andrea Savarino; Maria Aparecida Juliano; Ricardo Sobhie Diaz
Journal:  AIDS Res Ther       Date:  2022-01-12       Impact factor: 2.250

7.  Study of Viral Photoinactivation by UV-C Light and Photosensitizer Using a Pseudotyped Model.

Authors:  Mohammad Sadraeian; Fabio Francisco Pinto Junior; Marcela Miranda; Juliana Galinskas; Rafaela Sachetto Fernandes; Edgar Ferreira da Cruz; Libing Fu; Le Zhang; Ricardo Sobhie Diaz; Gustavo Cabral-Miranda; Francisco Eduardo Gontijo Guimarães
Journal:  Pharmaceutics       Date:  2022-03-21       Impact factor: 6.321

8.  Nicotinamide activates latent HIV-1 ex vivo in ART suppressed individuals, revealing higher potency than the association of two methyltransferase inhibitors, chaetocin and BIX01294.

Authors:  Sadia Samer; Muhammad Shoaib Arif; Leila Bertoni Giron; Jean Paulo Lopes Zukurov; James Hunter; Bruna Teresa Santillo; Gislene Namiyama; Juliana Galinskas; Shirley Vasconcelos Komninakis; Telma Miyuki Oshiro; Maria Cecilia Sucupira; Luiz Mario Janini; Ricardo Sobhie Diaz
Journal:  Braz J Infect Dis       Date:  2020-02-24       Impact factor: 3.257
  8 in total

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