OBJECTIVE: While cigarette smoking is the best-studied environmental factor contributing to rheumatoid arthritis (RA), no study to date has examined the influence of smoking cessation on disease activity. We examined this relationship in an observational cohort of patients with RA in the United States. METHODS: Patients enrolled in the Consortium of Rheumatology Researchers of North America registry (CORRONA) were stratified into never, former, and current smokers at enrollment. Current smokers were further stratified into continued and ceased smoking groups during their followup in the registry. The primary outcome was change in Clinical Disease Activity Index (CDAI) at last visit in a multivariate, random-effects regression model accounting for multiple timepoints. RESULTS: At last visit, there was no significant change in CDAI between ceased smokers and continued smokers (coefficient -0.00091, SE 0.0033, p = 0.7834). The study did confirm prior cross-sectional studies that current smokers have worse disease activity than former or never smokers. CONCLUSION: In the short term, smoking cessation did not appear to influence change in disease activity over time.
OBJECTIVE: While cigarette smoking is the best-studied environmental factor contributing to rheumatoid arthritis (RA), no study to date has examined the influence of smoking cessation on disease activity. We examined this relationship in an observational cohort of patients with RA in the United States. METHODS:Patients enrolled in the Consortium of Rheumatology Researchers of North America registry (CORRONA) were stratified into never, former, and current smokers at enrollment. Current smokers were further stratified into continued and ceased smoking groups during their followup in the registry. The primary outcome was change in Clinical Disease Activity Index (CDAI) at last visit in a multivariate, random-effects regression model accounting for multiple timepoints. RESULTS: At last visit, there was no significant change in CDAI between ceased smokers and continued smokers (coefficient -0.00091, SE 0.0033, p = 0.7834). The study did confirm prior cross-sectional studies that current smokers have worse disease activity than former or never smokers. CONCLUSION: In the short term, smoking cessation did not appear to influence change in disease activity over time.
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Authors: Yukinori Okada; Dorothee Diogo; Jeffrey D Greenberg; Faten Mouassess; Walid A L Achkar; Robert S Fulton; Joshua C Denny; Namrata Gupta; Daniel Mirel; Stacy Gabriel; Gang Li; Joel M Kremer; Dimitrios A Pappas; Robert J Carroll; Anne E Eyler; Gosia Trynka; Eli A Stahl; Jing Cui; Richa Saxena; Marieke J H Coenen; Henk-Jan Guchelaar; Tom W J Huizinga; Philippe Dieudé; Xavier Mariette; Anne Barton; Helena Canhão; João E Fonseca; Niek de Vries; Paul P Tak; Larry W Moreland; S Louis Bridges; Corinne Miceli-Richard; Hyon K Choi; Yoichiro Kamatani; Pilar Galan; Mark Lathrop; Towfique Raj; Philip L De Jager; Soumya Raychaudhuri; Jane Worthington; Leonid Padyukov; Lars Klareskog; Katherine A Siminovitch; Peter K Gregersen; Elaine R Mardis; Thurayya Arayssi; Layla A Kazkaz; Robert M Plenge Journal: PLoS One Date: 2014-02-10 Impact factor: 3.240
Authors: Ida K Roelsgaard; Eirik Ikdahl; Silvia Rollefstad; Grunde Wibetoe; Bente A Esbensen; George D Kitas; Piet van Riel; Sherine Gabriel; Tore K Kvien; Karen Douglas; Solveig Wållberg-Jonsson; Solbritt Rantapää Dahlqvist; George Karpouzas; Patrick H Dessein; Linda Tsang; Hani El-Gabalawy; Carol A Hitchon; Virginia Pascual-Ramos; Irazú Contreras-Yáñez; Petros P Sfikakis; Miguel A González-Gay; Cynthia S Crowson; Anne Grete Semb Journal: Rheumatology (Oxford) Date: 2020-08-01 Impact factor: 7.580