Literature DB >> 22421958

Stoichiometry of the slow I(ks) potassium channel in human embryonic stem cell-derived myocytes.

Mi Wang1, Robert S Kass.   

Abstract

The delayed rectifier I(ks) potassium channel is composed of α-(KCNQ1) and β-(KCNE1) subunits. The stoichiometry of I(ks) channels is a matter of some debate. Recently some investigators proposed that the number of KCNE1 subunits per KCNQ1 tetramer could be vary from one to four depending on the relative expression of these two genes. Here we review our previous study of biophysical properties of I(ks) in human embryonic stem cell-derived cardiomyocytes (hESC-CMs) showed that I(ks) in hESC-CMs is a coassembly channel with a stoichiometry other than 1:1, which could be further modulated by additional KCNE1.

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Year:  2012        PMID： 22421958     DOI： 10.1007/s00246-012-0255-2

Source DB:  PubMed          Journal:  Pediatr Cardiol        ISSN： 0172-0643            Impact factor:   1.655


  15 in total

1.  Electrophysiological characterization of cardiomyocytes derived from human induced pluripotent stem cells.

Authors:  Masaki Honda; Jumpei Kiyokawa; Mitsuyasu Tabo; Tomoaki Inoue
Journal:  J Pharmacol Sci       Date:  2011-10-25       Impact factor: 3.337

2.  The cardiac IKs channel, complex indeed.

Authors:  Jeremiah D Osteen; Kevin J Sampson; Robert S Kass
Journal:  Proc Natl Acad Sci U S A       Date:  2010-10-25       Impact factor: 11.205

3.  Counting membrane-embedded KCNE beta-subunits in functioning K+ channel complexes.

Authors:  Trevor J Morin; William R Kobertz
Journal:  Proc Natl Acad Sci U S A       Date:  2008-01-25       Impact factor: 11.205

Review 4.  New perspectives in stem cell research: beyond embryonic stem cells.

Authors:  C Leeb; M Jurga; C McGuckin; N Forraz; C Thallinger; R Moriggl; L Kenner
Journal:  Cell Prolif       Date:  2011-04       Impact factor: 6.831

5.  Progressive maturation in contracting cardiomyocytes derived from human embryonic stem cells: Qualitative effects on electrophysiological responses to drugs.

Authors:  Tomomi G Otsuji; Itsunari Minami; Yuko Kurose; Kaori Yamauchi; Masako Tada; Norio Nakatsuji
Journal:  Stem Cell Res       Date:  2010-02-06       Impact factor: 2.020

6.  Modelling long QT syndrome with iPS cells: be still, my beating heart ...

Authors:  G Tiscornia; N Monserrat; J C Izpisua Belmonte
Journal:  Circ Res       Date:  2011-03-18       Impact factor: 17.367

7.  Biophysical properties of slow potassium channels in human embryonic stem cell derived cardiomyocytes implicate subunit stoichiometry.

Authors:  Kai Wang; Cecile Terrenoire; Kevin J Sampson; Vivek Iyer; Jeremiah D Osteen; Jonathan Lu; Gordon Keller; Darrell N Kotton; Robert S Kass
Journal:  J Physiol       Date:  2011-10-24       Impact factor: 5.182

8.  Patient-specific induced pluripotent stem-cell models for long-QT syndrome.

Authors:  Alessandra Moretti; Milena Bellin; Andrea Welling; Christian Billy Jung; Jason T Lam; Lorenz Bott-Flügel; Tatjana Dorn; Alexander Goedel; Christian Höhnke; Franz Hofmann; Melchior Seyfarth; Daniel Sinnecker; Albert Schömig; Karl-Ludwig Laugwitz
Journal:  N Engl J Med       Date:  2010-07-21       Impact factor: 91.245

9.  Na+/Ca2+ exchanger is a determinant of excitation-contraction coupling in human embryonic stem cell-derived ventricular cardiomyocytes.

Authors:  Ji-Dong Fu; Peng Jiang; Stephanie Rushing; Jing Liu; Nipavan Chiamvimonvat; Ronald A Li
Journal:  Stem Cells Dev       Date:  2010-06       Impact factor: 3.272

10.  MinK-KvLQT1 fusion proteins, evidence for multiple stoichiometries of the assembled IsK channel.

Authors:  W Wang; J Xia; R S Kass
Journal:  J Biol Chem       Date:  1998-12-18       Impact factor: 5.157
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  6 in total

1.  Dynamic subunit stoichiometry confers a progressive continuum of pharmacological sensitivity by KCNQ potassium channels.

Authors:  Haibo Yu; Zhihong Lin; Margrith E Mattmann; Beiyan Zou; Cecile Terrenoire; Hongkang Zhang; Meng Wu; Owen B McManus; Robert S Kass; Craig W Lindsley; Corey R Hopkins; Min Li
Journal:  Proc Natl Acad Sci U S A       Date:  2013-05-06       Impact factor: 11.205

Review 2.  KCNQ1 channel modulation by KCNE proteins via the voltage-sensing domain.

Authors:  Koichi Nakajo; Yoshihiro Kubo
Journal:  J Physiol       Date:  2015-02-16       Impact factor: 5.182

3.  Individual IKs channels at the surface of mammalian cells contain two KCNE1 accessory subunits.

Authors:  Leigh D Plant; Dazhi Xiong; Hui Dai; Steve A N Goldstein
Journal:  Proc Natl Acad Sci U S A       Date:  2014-03-03       Impact factor: 11.205

4.  Control of Biophysical and Pharmacological Properties of Potassium Channels by Ancillary Subunits.

Authors:  Geoffrey W Abbott
Journal:  Handb Exp Pharmacol       Date:  2021

5.  Disease-linked mutations alter the stoichiometries of HCN-KCNE2 complexes.

Authors:  Yoann Lussier; Oliver Fürst; Eva Fortea; Marc Leclerc; Dimitri Priolo; Lena Moeller; Daniel G Bichet; Rikard Blunck; Nazzareno D'Avanzo
Journal:  Sci Rep       Date:  2019-06-24       Impact factor: 4.379

Review 6.  Insights into Cardiac IKs (KCNQ1/KCNE1) Channels Regulation.

Authors:  Xiaoan Wu; H Peter Larsson
Journal:  Int J Mol Sci       Date:  2020-12-11       Impact factor: 5.923
  6 in total

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