Pseudolysogeny.

Pseudolysogeny can be defined as the stage of stalled development of a bacteriophage in a host cell without either multiplication of the phage genome (as in lytic development) or its replication synchronized with the cell cycle and stable maintenance in the cell line (as in lysogenization), which proceeds with no viral genome degradation, thus allowing the subsequent restart of virus development. This phenomenon is usually caused by unfavorable growth conditions for the host cell (such as starvation) and is terminated with initiation of either true lysogenization or lytic growth when growth conditions improve. Pseudolysogeny has been known for tens of years; however, its role has often been underestimated. Currently, it is being considered more often as an important aspect of phage-host interactions. The reason for this is mostly an increased interest in phage-host interactions in the natural environment. Pseudolysogeny seems to play an important role in phage survival, as bacteria in a natural environment are starved or their growth is very slow. This phenomenon can be an important aspect of phage-dependent bacterial mortality and may influence the virulence of some bacterial strains. Copyright Â