Literature DB >> 2241977

The triterpene celastrol as a very potent inhibitor of lipid peroxidation in mitochondria.

H Sassa1, Y Takaishi, H Terada.   

Abstract

The inhibitory effect of the dienone-phenolic triterpene, celastrol, on lipid peroxidation in rat liver mitochondrial membranes induced by ADP and Fe2+ was studied. The anti-peroxidative effect of celastrol was very strong: its 50% inhibitory concentration was 7 microM, and it was about 15 times more effective than alpha-tocopherol. Celastrol scavenged 1.5 molar equivalents of radicals in homogeneous aqueous ethanolic solution, whereas cysteine and alpha-tocopherol scavenged one and two molar equivalents of radicals, respectively. The process of anti-peroxidation of celastrol was biphasic, possibly due to stepwise inhibitions of peroxidation in the outer and inner mitochondrial membranes.

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Year:  1990        PMID： 2241977     DOI： 10.1016/0006-291x(90)90759-g

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  18 in total

1.  Microarray-based gene expression profiling reveals the mediators and pathways involved in the anti-arthritic activity of Celastrus-derived Celastrol.

Authors:  Hua Yu; Shivaprasad H Venkatesha; Kamal D Moudgil
Journal:  Int Immunopharmacol       Date:  2012-06-02       Impact factor: 4.932

2.  Mitigating role of lupeol and lupeol linoleate on hepatic lipemic-oxidative injury and lipoprotein peroxidation in experimental hypercholesterolemia.

Authors:  V Sudhahar; S Ashok Kumar; P Varalakshmi; R Sundarapandiyan
Journal:  Mol Cell Biochem       Date:  2006-08-24       Impact factor: 3.396

3.  Role of Fe(III) in Fe(II)citrate-mediated peroxidation of mitochondrial membrane lipids.

Authors:  R F Castilho; A R Meinicke; A E Vercesi; M Hermes-Lima
Journal:  Mol Cell Biochem       Date:  1999-06       Impact factor: 3.396

4.  Celastrus treatment modulates antigen-induced gene expression in lymphoid cells of arthritic rats.

Authors:  H Yu; S H Venkatesha; S Nanjundaiah; L Tong; K D Moudgil
Journal:  Int J Immunopathol Pharmacol       Date:  2012 Apr-Jun       Impact factor: 3.219

5.  Celastrol from 'Thunder God Vine' protects SH-SY5Y cells through the preservation of mitochondrial function and inhibition of p38 MAPK in a rotenone model of Parkinson's disease.

Authors:  Bong-Suk Choi; Hyool Kim; Hyo Jeong Lee; Kumar Sapkota; Se Eun Park; Seung Kim; Sung-Jun Kim
Journal:  Neurochem Res       Date:  2013-11-09       Impact factor: 3.996

6.  Diabetes and mitochondrial oxidative stress: a study using heart mitochondria from the diabetic Goto-Kakizaki rat.

Authors:  Dario Loureiro Santos; Carlos Marques Palmeira; Raquel Seiça; José Dias; José Mesquita; António Joaquim Moreno; Maria Sancha Santos
Journal:  Mol Cell Biochem       Date:  2003-04       Impact factor: 3.396

7.  Reduction of beta-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease.

Authors:  Daniel Paris; Nowell J Ganey; Vincent Laporte; Nikunj S Patel; David Beaulieu-Abdelahad; Corbin Bachmeier; Amelia March; Ghania Ait-Ghezala; Michael J Mullan
Journal:  J Neuroinflammation       Date:  2010-03-08       Impact factor: 8.322

8.  Celastrol and Its Role in Controlling Chronic Diseases.

Authors:  Shivaprasad H Venkatesha; Kamal D Moudgil
Journal:  Adv Exp Med Biol       Date:  2016       Impact factor: 2.622

9.  Characteristics of Fe(II)ATP complex-induced damage to the rat liver mitochondrial membrane.

Authors:  M Hermes-Lima; R F Castilho; A R Meinicke; A E Vercesi
Journal:  Mol Cell Biochem       Date:  1995-04-12       Impact factor: 3.396

10.  Celastrol pretreatment as a therapeutic option against cisplatin-induced nephrotoxicity.

Authors:  Tugce Boran; Aysenur Gunaydin; Ayse Tarbin Jannuzzi; Eren Ozcagli; Buket Alpertunga
Journal:  Toxicol Res (Camb)       Date:  2019-07-31       Impact factor: 3.524
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