Literature DB >> 22419716

A population-based prospective cohort study of complications after thyroidectomy in the elderly.

Raymon H Grogan1, Elliot J Mitmaker, Jimmy Hwang, Jessica E Gosnell, Quan-Yang Duh, Orlo H Clark, Wen T Shen.   

Abstract

CONTEXT: Data on the risk of postthyroidectomy complications in elderly patients are sparse, unclear, and conflicting.
OBJECTIVE: We sought to use a population-based cohort to determine whether thyroid operations in the elderly are as safe as those done in younger patients.
DESIGN: This was a prospective cohort study using the American College of Surgeons National Surgical Quality Improvement Program database from 2005 to 2008, with 30-d postoperative follow-up.
SETTING: The American College of Surgeons National Surgical Quality Improvement Program data set contains operative cases from a nationwide sampling of academic and community-based as well as high-volume and low-volume hospitals. PATIENTS: All thyroidectomy and parathyroidectomy patients reported to the database during the study period were included in the analysis resulting in an experimental cohort of 7915 thyroidectomy cases and a control cohort of 3575 parathyroidectomy cases. MAIN OUTCOME MEASURES: We aggregated 83 complications into the following outcome measures: urinary tract infection, wound infection, systemic infection, cardiac complications, pulmonary complications, 30-d mortality, and total hospital length of stay.
RESULTS: Increased age is a risk factor for significant pulmonary, cardiac, and infectious complications after thyroidectomy. Elderly patients are twice as likely (odds ratio 2.1, 95% confidence interval 1.4-3.3), and the superelderly are 5 times as likely (odds ratio 4.9, 95% confidence interval 2.5-9.6) to have a complication compared with their young counterparts. Preexisting comorbidities are effect modifiers and increase the risk of complications even further.
CONCLUSIONS: Elderly thyroidectomy patients are at increased risk for major systemic complications. A systematic approach to the care of elderly thyroidectomy patients is necessary to minimize their risk of serious postoperative complications.

Entities:  

Mesh:

Year:  2012        PMID: 22419716     DOI: 10.1210/jc.2011-1162

Source DB:  PubMed          Journal:  J Clin Endocrinol Metab        ISSN: 0021-972X            Impact factor:   5.958


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