Literature DB >> 2241971

Inositol trisphosphate and thapsigargin discriminate endoplasmic reticulum stores of calcium in rat brain.

A Verma1, D J Hirsch, M R Hanley, O Thastrup, S B Christensen, S H Snyder.   

Abstract

ATP dependent Ca2+ accumulation into oxalate-loaded rat brain microsomes is potently inhibited by thapsigargin with an IC50 of 2 nM and maximal inhibition at 10 nM. Approximately 15% of the total A23187-releasable microsomal calcium store is insensitive to thapsigargin concentrations up to 100 microM. Inositol-1,4,5-trisphosphate (IP3) maximally inhibits 40% of the net Ca2+ accumulation by whole brain microsomes. Its effects are non-additive with thapsigargin suggesting that the IP3-sensitive Ca2+ pool is a subset of the thapsigargin sensitive Ca2+ pool. Marked regional differences occur in Ca2+ transport rates and sensitivity to both thapsigargin and IP3.

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Year:  1990        PMID： 2241971     DOI： 10.1016/0006-291x(90)90747-b

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  18 in total

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4.  Action of 5-hydroxytryptamine in facilitating N-methyl-D-aspartate depolarization of cortical neurones mimicked by calcimycin, cyclopiazonic acid and thapsigargin.

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Authors:  T Ozawa; F Thévenod; I Schulz
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8.  Ryanodine-sensitive, thapsigargin-insensitive calcium uptake in rat ventricle homogenates.

Authors:  J J Feher; K N Lee; Q Y Wu
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9.  Calcium pools mobilized by calcium or inositol 1,4,5-trisphosphate are differentially localized in rat heart and brain.

Authors:  A Verma; D J Hirsch; S H Snyder
Journal:  Mol Biol Cell       Date:  1992-06       Impact factor: 4.138

10.  Mobilization of Ca2+ by thapsigargin and 2,5-di-(t-butyl)-1,4-benzohydroquinone in permeabilized insulin-secreting RINm5F cells: evidence for separate uptake and release compartments in inositol 1,4,5-trisphosphate-sensitive Ca2+ pool.

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Journal:  Biochem J       Date:  1993-07-15       Impact factor: 3.857
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