BACKGROUND: Neuronal circuit assembly comprises a number of developmental processes that ultimately underlie function. Identifying the molecular events that dictate these processes can give key insights into how neuronal circuit formation is coordinated. To begin to identify such molecular mechanisms, we have analysed the expression of a candidate gene of entirely unknown function within the nervous system. Here we reveal the spatial and temporal distribution of Lzts1 in mouse and chick embryonic spinal cord and propose potential biological functions. RESULTS: Lzts1 mRNA is transiently expressed at the border of the ventricular and mantle zones in subsets of sensory and motor spinal neurons. The protein is localized to the cell body, axon, and trailing process of motor, commissural, and dorsal root neurons during development. CONCLUSIONS: Taken together, the spatial and temporal distribution of Lzts1 is consistent with a potential function(s) in cell cycle regulation, axon growth or guidance, and/or migration of neurons.
BACKGROUND: Neuronal circuit assembly comprises a number of developmental processes that ultimately underlie function. Identifying the molecular events that dictate these processes can give key insights into how neuronal circuit formation is coordinated. To begin to identify such molecular mechanisms, we have analysed the expression of a candidate gene of entirely unknown function within the nervous system. Here we reveal the spatial and temporal distribution of Lzts1 in mouse and chickembryonic spinal cord and propose potential biological functions. RESULTS:Lzts1 mRNA is transiently expressed at the border of the ventricular and mantle zones in subsets of sensory and motor spinal neurons. The protein is localized to the cell body, axon, and trailing process of motor, commissural, and dorsal root neurons during development. CONCLUSIONS: Taken together, the spatial and temporal distribution of Lzts1 is consistent with a potential function(s) in cell cycle regulation, axon growth or guidance, and/or migration of neurons.
Authors: T Kawaue; A Shitamukai; A Nagasaka; Y Tsunekawa; T Shinoda; K Saito; R Terada; M Bilgic; T Miyata; F Matsuzaki; A Kawaguchi Journal: Nat Commun Date: 2019-06-25 Impact factor: 14.919
Authors: Benjamin Joel Wheaton; Sara Lea Häggström; Mridula Muppavarapu; Luz María González-Castrillón; Sara Ivy Wilson Journal: Dev Dyn Date: 2022-03-18 Impact factor: 2.842
Authors: Maud Wurmser; Mridula Muppavarapu; Christine Mary Tait; Christophe Laumonnerie; Luz María González-Castrillón; Sara Ivy Wilson Journal: Front Cell Dev Biol Date: 2021-06-23
Authors: Ayden Saffari; Smeeta Shrestha; Prachand Issarapu; Sara Sajjadi; Modupeh Betts; Sirazul Ameen Sahariah; Ashutosh Singh Tomar; Philip James; Akshay Dedaniya; Dilip K Yadav; Kalyanaraman Kumaran; Andrew M Prentice; Karen A Lillycrop; Caroline H D Fall; Giriraj R Chandak; Matt J Silver Journal: Am J Clin Nutr Date: 2020-10-01 Impact factor: 7.045